PEG-NH 2-modified upconverting nanoparticles(near-infrared light), 10 mgProduct Type: Upconverting nanoparticle
Research-grade laboratory product
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
LABORATORY PROCUREMENT SUPPORT
For model selection, material format, solvent, concentration or configuration confirmation, contact our technical sales team.
E-MAIL: inquiry@atomfair.com
|
|||||||||||||||||||||||||||||||
|
Manufacturer: Atomfair LLC
Brand: ATOMFAIR®
|
Manufacturer: Atomfair LLC
Brand: ATOMFAIR®
How does the 804 nm near-infrared emission of these PEG-NH2-modified upconverting nanoparticles impact their performance for deep-tissue imaging compared to visible-emitting UCNPs?
The 804 nm emission wavelength places these particles in the near-infrared biological window, enabling deeper tissue penetration and reduced autofluorescence compared to visible-light emitters. This configuration uses NaYREF4 host material with a 35 nm particle size, which balances luminescence efficiency with cellular uptake potential. The PEG-NH2 surface modification further improves aqueous stability and biocompatibility for in vivo applications.
What are the critical compatibility constraints when using these PEG-NH2-modified upconverting nanoparticles (NaYREF4, 35 nm, 804 nm emission) in biological buffer systems?
These nanoparticles are supplied with water as the solvent and are PEG-NH2-functionalized, making them directly compatible with aqueous biological buffers. However, users must confirm the final concentration and dispersion format—powder or pre-dispersed—before use, as the product is supplied in a 10 mg package size. The amine-terminated PEG surface allows for further bioconjugation, but buffers containing high salt or extreme pH may require optimization to prevent aggregation or loss of upconversion efficiency.
What handling and storage conditions are recommended for these PEG-NH2-modified upconverting nanoparticles (10 mg, 35 nm) to preserve their luminescence and colloidal stability?
The product is supplied as a 10 mg solid or dispersion in water. For long-term storage, keep the material in a sealed, light-protected container at 2–8 °C to prevent photodegradation and aggregation of the 35 nm NaYREF4 particles. Prior to use, verify the concentration and redisperse in water if needed; avoid repeated freeze-thaw cycles if working with the aqueous dispersion. These precautions ensure the 804 nm upconversion emission remains stable for research applications.
This PEG-NH2-modified upconverting nanoparticle (NaYREF4, 35 nm, 804 nm emission) is supplied as a 10 mg powder in water, optimized for near-infrared excitation and bioconjugation workflows, but requires careful handling to maintain surface functionalization and colloidal stability.
Positive
- Near-infrared excitation and emission: The 804 nm emission wavelength enables deep-tissue imaging with reduced autofluorescence and photodamage, a key advantage for in vivo biological applications.
- PEG-NH2 surface functionalization: The PEG-NH2 modification provides colloidal stability in aqueous media and primary amine groups for direct bioconjugation to antibodies or targeting ligands, streamlining assay development.
Trade-offs
- Small particle size handling: At 35 nm diameter, these nanoparticles are prone to aggregation if solvent conditions (pH, ionic strength) deviate from the supplied water dispersion, requiring careful buffer optimization before use.
- Limited package size for scale-up: The 10 mg package size is suitable for proof-of-concept studies but may necessitate multiple orders for extended in vivo or multiplexed experiments, increasing batch-to-batch variability risk.
Every advanced material, component, equipment, and instrument in our catalog is backed by rigorous testing. We maintain strict internal quality management frameworks and align with CE conformity metrics to deliver transparent, reproducible performance data via our public open-science repository.
To request raw batch performance data, submit formal vendor registration paperwork, or execute a fast-turnaround R&D manufacturing loop, contact us at inquiry@atomfair.com.
Item is dispatched under the Atomfair Shipping & Delivery Framework (Free worldwide shipping on orders over $59 USD excl. heavy equipment). Return is governed by the Atomfair Return & Refund Policy (7-day technical return window).
