Description

Diethyl Ethylphosphonate (CAS 78-38-6) is a high-purity organophosphorus compound with the molecular formula C₆H₁₅O₃P and IUPAC name 1-[ethoxy(ethyl)phosphoryl]oxyethane. This colorless to pale yellow liquid is widely used in organic synthesis, pharmaceutical intermediates, and as a flame retardant precursor. With a molecular weight of 166.16 g/mol, it offers excellent solubility in common organic solvents while being sparingly soluble in water. Our product is rigorously tested to ensure ≥98% purity (GC), with low levels of moisture and heavy metals. Packaged under inert gas in amber glass bottles or specialized chemical containers to ensure stability. Suitable for use in Grignard reactions, Horner-Wadsworth-Emmons olefination, and as a ligand in metal catalysis. SDS and analytical certificates available upon request.

Properties

• CAS Number: 78-38-6
• Complexity: 114
• IUPAC Name: 1-[ethoxy(ethyl)phosphoryl]oxyethane
• InChI: InChI=1S/C6H15O3P/c1-4-8-10(7,6-3)9-5-2/h4-6H2,1-3H3
• InChI Key: AATNZNJRDOVKDD-UHFFFAOYSA-N
• Exact Mass: 166.07588133
• Molecular Formula: C6H15O3P
• Molecular Weight: 166.16
• SMILES: CCOP(=O)(CC)OCC
• Topological: 35.5
• Monoisotopic Mass: 166.07588133
• Physical Description: Diethyl ethylphosphonate is a colorless liquid with a mild odor.
• Color/Form: COLORLESS LIQ
• Odor: SWEET
• Boiling Point: 180 to 181 °F at 11 mmHg
• Melting Point: 388 °F
• Flash Point: 220 °F
• Solubility: Slightly soluble
• Density: 1.0259 at 68 °F – Denser than water; will sink
• Vapor Density: 5.73
• Vapor Pressure: 0.31 [mmHg]
• Stability/Shelf Life: STABLE
• Refractive Index: INDEX OF REFRACTION: 1.4163 @ 20 °C/D
• Synonyms: DIETHYL ETHYLPHOSPHONATE, 78-38-6, Diethyl ethanephosphonate, Phosphonic acid, ethyl-, diethyl ester, Ethanephosphonic acid, diethyl ester, CCRIS 6230, HSDB 2560, Diethoxyethylphosphine oxide, NSC 2671, EINECS 201-111-9, UNII-Y52Q01P44T, DTXSID7025051, Amgard v 490, AI3-18558, Y52Q01P44T, NSC-2671, DTXCID405051, ethanephosphonic acid diethyl ester, ETHYLDIETHOXYPHOSPHINE OXIDE, Phosphonic acid, ethyl, diethyl ester, 201-111-9, aatnznjrdovkdd-uhfffaoysa-n, inchi=1/c6h15o3p/c1-4-8-10(7,6-3)9-5-2/h4-6h2,1-3h, 1-[ethoxy(ethyl)phosphoryl]oxyethane, Diethylethylphosphonate, Diethylethanephosphonate, SCHEMBL26483, MLS001050132, SCHEMBL1610836, SCHEMBL5961215, SCHEMBL6631037, CHEMBL1299387, NSC2671, Ethylphosphonic Acid Diethyl Ester, ethyl-phosphonic acid diethyl ester, Ethylphosphonic acid, diethyl ester, Tox21_200361, AKOS015839010, CAS-78-38-6, NCGC00091203-01, NCGC00091203-02, NCGC00257915-01, AC-37980, Phosphonic acid, P-ethyl-, diethyl ester, SMR001216581, Diethyl ethylphosphonate, >=98.0% (GC), DB-056306, E0483, NS00019579, F17208, Q27294279

Application

Diethyl ethylphosphonate serves as a key intermediate in pharmaceutical synthesis, particularly for antiviral and anticancer agents. It is employed as a precursor for flame-retardant additives in polymers and textiles. The compound also functions as a solvent and stabilizer in specialty chemical formulations. Researchers utilize it in organic transformations, including the preparation of α,β-unsaturated esters via phosphonate chemistry. Its metal-chelating properties make it valuable in catalytic systems and material science applications.

Safety and Hazards

GHS Hazard Statements

• H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H318 (98.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H411 (99.2%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P264+P265, P270, P273, P280, P301+P317, P305+P354+P338, P317, P330, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (99.2%)
• Eye Dam. 1 (98.4%)
• Aquatic Chronic 2 (99.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.