Description

Diethylsulfamyl Fluoride (CAS 382-97-8) is a highly specialized organofluorine compound with the molecular formula C₄H₁₀FNO₂S. Also known as N,N-Diethylsulfamoyl fluoride, this chemical is a valuable reagent for researchers in synthetic organic chemistry, medicinal chemistry, and materials science. Its unique sulfamoyl fluoride moiety makes it an effective electrophile for modifying nucleophilic sites in peptides, proteins, and other biomolecules. The compound is characterized by its high purity (>95%) and stability under controlled conditions, ensuring reliable performance in laboratory applications. Suitable for use as a building block in the synthesis of sulfonamide derivatives or as a probe in chemical biology studies. Available in sealed glass vials under inert atmosphere to preserve integrity. Handle with appropriate safety precautions, including fume hood use and personal protective equipment (PPE).

Properties

• CAS Number: 382-97-8
• Complexity: 156
• IUPAC Name: N,N-diethylsulfamoyl fluoride
• InChI: InChI=1S/C4H10FNO2S/c1-3-6(4-2)9(5,7)8/h3-4H2,1-2H3
• InChI Key: AILVSTFKSUSWNR-UHFFFAOYSA-N
• Exact Mass: 155.04162790
• Molecular Formula: C4H10FNO2S
• Molecular Weight: 155.19
• SMILES: CCN(CC)S(=O)(=O)F
• Topological: 45.8
• Monoisotopic Mass: 155.04162790
• Synonyms: 382-97-8, Diethylsulfamyl fluoride, DTXSID10602216, DTXCID00552973, N,N-Diethylsulfamoyl fluoride, diethylsulfamoyl fluoride, N,N-Diethylsulfamoylfluoride, SCHEMBL9220303, CS-0258544, G89776, EN300-7048744

Application

Diethylsulfamyl fluoride is primarily used as a reactive intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals. Its electrophilic fluorine atom enables selective modification of proteins and enzymes, making it useful for activity-based protein profiling (ABPP) in proteomics research. The compound also serves as a precursor for designing covalent inhibitors targeting serine hydrolases and other nucleophilic enzymes.

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.