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Atomfair Silanol, 1,1,1-trimethyl-, 1-acetate TMSOAc C5H12O2Si CAS 2754-27-0

Trimethylsilyl Acetate (CAS No. 2754-27-0), also known as Acetoxytrimethylsilane, is a highly versatile organosilicon compound with the molecular formula C5H12O2Si. This clear, colorless liquid is widely used in organic synthesis, particularly as a silylating agent for protecting hydroxyl groups and as a precursor in the production of advanced materials. Its exceptional reactivity and stability make it a valuable reagent for researchers and scientists working in pharmaceuticals, agrochemicals, and polymer chemistry. Packaged under inert gas to ensure purity and longevity, our high-grade Trimethylsilyl Acetate (≥97%) is ideal for sensitive applications requiring precise control over reaction conditions. Available in various quantities to…

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Description

Trimethylsilyl Acetate (CAS No. 2754-27-0), also known as Acetoxytrimethylsilane, is a highly versatile organosilicon compound with the molecular formula C5H12O2Si. This clear, colorless liquid is widely used in organic synthesis, particularly as a silylating agent for protecting hydroxyl groups and as a precursor in the production of advanced materials. Its exceptional reactivity and stability make it a valuable reagent for researchers and scientists working in pharmaceuticals, agrochemicals, and polymer chemistry. Packaged under inert gas to ensure purity and longevity, our high-grade Trimethylsilyl Acetate (≥97%) is ideal for sensitive applications requiring precise control over reaction conditions. Available in various quantities to suit lab-scale and industrial needs.

Properties

  • CAS Number: 2754-27-0
  • Complexity: 93.1
  • IUPAC Name: trimethylsilyl acetate
  • InChI: InChI=1S/C5H12O2Si/c1-5(6)7-8(2,3)4/h1-4H3
  • InChI Key: QHUNJMXHQHHWQP-UHFFFAOYSA-N
  • Exact Mass: 132.060656156
  • Molecular Formula: C5H12O2Si
  • Molecular Weight: 132.23
  • SMILES: CC(=O)O[Si](C)(C)C
  • Topological: 26.3
  • Monoisotopic Mass: 132.060656156
  • Synonyms: Trimethylsilyl acetate, 2754-27-0, Acetoxytrimethylsilane, Trimethylacetoxysilane, Silanol, 1,1,1-trimethyl-, 1-acetate, (Acetato)trimethylsilane, Silanol, trimethyl-, acetate, NSC 96780, EINECS 220-404-2, DTXSID90883723, DTXCID601020988, Ethyl (2E)-2-cyano-3-(1H-indolyl-3-yl)acrylate, 220-404-2, 636-365-3, Acetic Acid Trimethylsilyl Ester, TRIMETHYLSILYLACETATE, Acetic acid, TMS derivative, LXX47M44WG, NSC-96780, Silanol, acetate, TMSOAc, MFCD00008695, o-trimethylsilylacetate, Acetyloxytrimethylsilane, Trimethylsilyl acetate, trimethylsilyl ethanoate, CH3COOSi(CH3)3, UNII-LXX47M44WG, NCIOpen2_001849, Trimethylsilyl acetate, 97%, SCHEMBL338658, SCHEMBL4644967, NSC96780, AKOS015892883, CS-W011087, FS-3997, BP-21426, DB-318549, NS00049728, E75967, S00009, A819111

Trimethylsilyl Acetate is commonly employed as a protecting group for alcohols in multistep organic syntheses, particularly in peptide and carbohydrate chemistry. It serves as a mild acetylating agent in the preparation of silicon-containing polymers and resins. Additionally, it is used in the derivatization of polar compounds for GC-MS analysis to improve volatility and detection sensitivity.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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