Description
Bis(trimethylsilyl) sulfate (CAS No. 18306-29-1) is a highly specialized organosilicon compound with the molecular formula C6H18O4SSi2. This reagent is widely recognized for its role as a silylating agent, particularly in the protection of hydroxyl groups and the synthesis of sensitive intermediates. Its unique structure, featuring two trimethylsilyl groups bonded to a sulfate moiety, ensures excellent reactivity in organic transformations. Ideal for laboratory and industrial applications, this compound is rigorously purified to meet the highest standards of purity and consistency. Packaged under inert conditions to ensure stability, it is a critical tool for researchers in pharmaceuticals, materials science, and fine chemical synthesis.
Properties
- CAS Number: 18306-29-1
- Complexity: 232
- IUPAC Name: bis(trimethylsilyl) sulfate
- InChI: InChI=1S/C6H18O4SSi2/c1-12(2,3)9-11(7,8)10-13(4,5)6/h1-6H3
- InChI Key: KRUQDZRWZXUUAD-UHFFFAOYSA-N
- Exact Mass: 242.04643329
- Molecular Formula: C6H18O4SSi2
- Molecular Weight: 242.44
- SMILES: C[Si](C)(C)OS(=O)(=O)O[Si](C)(C)C
- Topological: 61
- Monoisotopic Mass: 242.04643329
- Synonyms: Bis(trimethylsilyl) sulfate, 18306-29-1, Bis(trimethylsilyl)sulfate, Silanol, trimethyl-, 1,1′-sulfate, Bistrimethylsilylsulfate, Sulfuric acid, TMS, ditrimethylsilyl sulfate, bis(trimethylsilyl)sulphate, Bis(trimethylsilyl) sulphate, EINECS 242-192-0, MFCD00008268, Silanol, trimethyl-, sulfate (2:1), bistrimethylsilyl sulfate, bis-(trimethylsilyl)-sulfate, SCHEMBL495294, 4K4D2P4A3D, Sulfuric acid, 2TMS derivative, DTXSID20171382, Sulfuric acid, bis(trimethylsilyl)-, AKOS015856681, Sulfuric acid, bis(trimethylsilyl) ester, BS-43923, DB-044484, B1245, CS-0128851, NS00051545, D88773, S02810
Application
Bis(trimethylsilyl) sulfate is primarily used as a silylating agent for the protection of hydroxyl groups in organic synthesis. It is also employed in the preparation of silyl ethers, which are key intermediates in the production of pharmaceuticals and agrochemicals. Additionally, this compound finds utility in the modification of surfaces and polymers, enhancing their hydrophobicity and chemical resistance.
Safety and Hazards
GHS Hazard Statements
- H228 (100%): Flammable solid [Danger Flammable solids]
- H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statements
- P210, P240, P241, P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P405, and P501
Hazard Classes and Categories
- Flam. Sol. 2 (100%)
- Skin Corr. 1C (100%)
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