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Atomfair Ethoxytrimethylsilane ETMS, Trimethylethoxysilane C5H14OSi CAS 1825-62-3

Ethoxytrimethylsilane (CAS No. 1825-62-3) is a highly versatile organosilicon compound with the molecular formula C5H14OSi. This clear, colorless liquid is widely used in organic synthesis, surface modification, and as a protecting group for alcohols due to its reactivity and stability. Ethoxytrimethylsilane is particularly valued for its role in silylation reactions, where it serves as an effective ethoxytrimethylsilyl (ETMS) donor. With a purity of 98%, it is suitable for laboratory research, pharmaceutical development, and industrial applications requiring precise silicon-based reagents. Its low viscosity and volatility make it ideal for coatings, adhesives, and sealants. Store in a cool, dry place under inert…

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Description

Ethoxytrimethylsilane (CAS No. 1825-62-3) is a highly versatile organosilicon compound with the molecular formula C5H14OSi. This clear, colorless liquid is widely used in organic synthesis, surface modification, and as a protecting group for alcohols due to its reactivity and stability. Ethoxytrimethylsilane is particularly valued for its role in silylation reactions, where it serves as an effective ethoxytrimethylsilyl (ETMS) donor. With a purity of 98%, it is suitable for laboratory research, pharmaceutical development, and industrial applications requiring precise silicon-based reagents. Its low viscosity and volatility make it ideal for coatings, adhesives, and sealants. Store in a cool, dry place under inert gas to maintain stability.

Properties

  • CAS Number: 1825-62-3
  • Complexity: 46.5
  • IUPAC Name: ethoxy(trimethyl)silane
  • InChI: InChI=1S/C5H14OSi/c1-5-6-7(2,3)4/h5H2,1-4H3
  • InChI Key: RSIHJDGMBDPTIM-UHFFFAOYSA-N
  • Exact Mass: 118.081391600
  • Molecular Formula: C5H14OSi
  • Molecular Weight: 118.25
  • SMILES: CCO[Si](C)(C)C
  • Topological: 9.2
  • Monoisotopic Mass: 118.081391600
  • Physical Description: Liquid
  • Synonyms: ETHOXYTRIMETHYLSILANE, Silane, trimethylethoxy-, Ethyl trimethylsilyl ether, Trimethylsilyl ethyl ether, NSC 43345, EINECS 217-370-6, BRN 1731950, UNII-82883M7A40, NSC-43345, 82883M7A40, DTXSID5051814, 4-04-00-03994 (Beilstein Handbook Reference), DTXCID0030370, 217-370-6, Trimethylethoxysilane, 1825-62-3, Silane, ethoxytrimethyl-, ethoxy(trimethyl)silane, CT2970, MFCD00009069, trimethyl ethoxy silane, Ethanol, TMS derivative, Ethoxytrimethylsilane, 98%, SCHEMBL27813, SCHEMBL754355, SCHEMBL990561, EXP-51, SCHEMBL6053994, SCHEMBL15194659, NSC43345, WLN: 2O-SI-1&1&1, AKOS015914898, LS-13107, DB-029726, NS00045705, T1394, EN300-185544, S08635, W13860, A812704, Q27269318

Ethoxytrimethylsilane is primarily used as a silylating agent in organic synthesis to protect hydroxyl groups during multi-step reactions. It is also employed in surface modification to enhance hydrophobicity in materials like glass, silica, and polymers. Additionally, it serves as a precursor in the production of silicone-based compounds and specialty chemicals.

Safety and Hazards

GHS Hazard Statements

  • H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
  • H302 (40.7%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (46%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (46%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (45.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 2 (100%)
  • Acute Tox. 4 (40.7%)
  • Skin Irrit. 2 (46%)
  • Eye Irrit. 2 (46%)
  • STOT SE 3 (45.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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