Description

Difluoromethanesulfonyl Fluoride (CHF₃O₂S) is a highly specialized fluorinated sulfonyl fluoride compound, primarily utilized in advanced chemical synthesis and material science research. With a CAS number of 1554-47-8, this reagent is characterized by its reactive sulfonyl fluoride group, making it a valuable intermediate in the preparation of sulfonamides, sulfonate esters, and other sulfur-containing derivatives. Its molecular formula, CHF₃O₂S, reflects its unique structure, which combines difluoromethane with a sulfonyl fluoride moiety, offering exceptional reactivity in nucleophilic substitution reactions.

This compound is supplied as a high-purity liquid, ensuring consistency and reliability for sensitive applications. It is particularly useful in pharmaceutical research, agrochemical development, and the synthesis of specialty polymers. Proper handling under inert conditions is recommended due to its moisture sensitivity and potential reactivity. Researchers can trust this product for its quality, precision, and suitability for demanding synthetic workflows.

Properties

• CAS Number: 1554-47-8
• Complexity: 130
• IUPAC Name: difluoromethanesulfonyl fluoride
• InChI: InChI=1S/CHF3O2S/c2-1(3)7(4,5)6/h1H
• InChI Key: OEDFBJZWAYJCHE-UHFFFAOYSA-N
• Exact Mass: 133.96493493
• Molecular Formula: CHF3O2S
• Molecular Weight: 134.08
• SMILES: C(F)(F)S(=O)(=O)F
• Topological: 42.5
• Monoisotopic Mass: 133.96493493
• Synonyms: DIFLUOROMETHANESULFONYL FLUORIDE, 1554-47-8, DTXSID50537891, DTXCID10488678, Methanesulfonyl fluoride, 1,1-difluoro-, difluoromethanesulfonylfluoride, CHF3O2S, SCHEMBL136590, SCHEMBL2350698, OEDFBJZWAYJCHE-UHFFFAOYSA-N, AKOS005063797, ES-2174, DB-001354, CS-0437763, EN300-64016, G33759

Application

Difluoromethanesulfonyl fluoride is widely employed as a key intermediate in organic synthesis, particularly for introducing sulfonyl groups into target molecules. It is used in the preparation of sulfonamide-based pharmaceuticals and agrochemicals due to its high reactivity with amines. Additionally, this compound serves as a precursor in the development of specialty polymers and advanced materials with tailored properties. Its unique fluorinated structure also makes it valuable in the study of fluorine chemistry and catalytic processes.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Acute Tox. 4 (100%)
• Skin Corr. 1B (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.