Description

2,4-Difluoro-1,1′-biphenyl (CAS No. 37847-52-2) is a high-purity organic compound with the molecular formula C₁₂H₈F₂. This fluorinated biphenyl derivative is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its rigid biphenyl core and strategically positioned fluorine atoms make it an excellent intermediate for Suzuki coupling, cross-coupling reactions, and the synthesis of liquid crystals or OLED materials. Available in >97% purity, this compound is rigorously tested via GC/MS, NMR, and HPLC to ensure consistency for demanding applications. Packaged under inert gas to prevent degradation, it is ideal for use in medicinal chemistry, catalysis, and advanced material development.

Properties

• CAS Number: 37847-52-2
• Complexity: 175
• IUPAC Name: 2,4-difluoro-1-phenyl-benzene
• InChI: InChI=1S/C12H8F2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H
• InChI Key: JVHAJKHGPDDEEU-UHFFFAOYSA-N
• Exact Mass: 190.05940658
• Molecular Formula: C12H8F2
• Molecular Weight: 190.19
• SMILES: C1=CC=C(C=C1)C2=C(C=C(C=C2)F)F
• Monoisotopic Mass: 190.05940658
• Synonyms: 2,4-Difluorobiphenyl, 37847-52-2, 2,4-Difluoro-1,1′-biphenyl, 1,1′-Biphenyl, 2,4-difluoro-, EINECS 253-690-2, DTXSID70191277, DTXCID80113768, 253-690-2, 2,4-difluoro-1-phenylbenzene, 2,4-Difluoro-1,1-biphenyl, 2,4-Difluoro-1,1′-biphenyl; 2,4-Difluoro-1-phenylbenzene; 2,4-Difluorobiphenyl;, MFCD00042515, 2,4-Difluoro-biphenyl, 2′,4′-difluorobiphenyl, RR42FH7YWL, SCHEMBL412228, SCHEMBL435274, SCHEMBL435275, SCHEMBL694142, CHEMBL121977, 2,4 Difluoro-1,1′-biphenyl, 2,4-Difluoro-1-phenyl-benzene, SCHEMBL10428951, JVHAJKHGPDDEEU-UHFFFAOYSA-, SBB091095, AKOS006230003, 2,4-Difluoro-1,1′-biphenyl, 97%, CS-W015898, AC-10689, AS-13070, DB-019937, D3450, NS00057669, D90192, InChI=1/C12H8F2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H

2,4-Difluoro-1,1′-biphenyl serves as a key precursor in the synthesis of fluorinated liquid crystals for display technologies. Its electron-withdrawing fluorine substituents enhance reactivity in palladium-catalyzed cross-coupling reactions, making it valuable for drug discovery. Researchers also utilize it to modify polymer backbones for improved thermal stability in high-performance materials.

Safety and Hazards

GHS Hazard Statements

• H302 (92.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (95.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (92.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (92.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H400 (92.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (92.9%)
• Skin Irrit. 2 (95.2%)
• Eye Dam. 1 (92.9%)
• STOT SE 3 (92.9%)
• Aquatic Acute 1 (92.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.