Description

Trimethylene Carbonate (TMC) is a high-purity cyclic carbonate monomer with the molecular formula C₄H₆O₃ and CAS number 2453-03-4. Also known as 1,3-dioxan-2-one, this versatile compound is widely utilized in polymer chemistry, biomedical engineering, and specialty material synthesis. Its six-membered ring structure provides excellent reactivity for ring-opening polymerization (ROP), making it a key precursor for biodegradable polycarbonates and poly(trimethylene carbonate) (PTMC).

Our TMC is rigorously tested for purity, ensuring optimal performance in demanding applications such as drug delivery systems, resorbable medical implants, and eco-friendly plastics. It is supplied as a white crystalline solid with high solubility in common organic solvents like dichloromethane and tetrahydrofuran. Suitable for controlled reactions, TMC offers low toxicity and superior biocompatibility, meeting ISO 10993-5 standards for medical-grade materials.

Key Features:

• ≥99% purity (HPLC/GC)
• Low residual moisture (<0.1%)
• Controlled endotoxin levels for biomedical use
• Stable under inert atmosphere storage

Properties

• CAS Number: 2453-03-4
• Complexity: 71
• IUPAC Name: 1,3-dioxan-2-one
• InChI: InChI=1S/C4H6O3/c5-4-6-2-1-3-7-4/h1-3H2
• InChI Key: YFHICDDUDORKJB-UHFFFAOYSA-N
• Exact Mass: 102.031694049
• Molecular Formula: C4H6O3
• Molecular Weight: 102.09
• SMILES: C1COC(=O)OC1
• Topological: 35.5
• Monoisotopic Mass: 102.031694049
• Synonyms: Trimethylene Carbonate, 2453-03-4, 1,3-Carbonyldioxypropane, m-Dioxan-2-one, Cyclic trimethylene carbonate, 1,3-Propanediol, cyclic carbonate, 4316AQ174Q, UNII-4316AQ174Q, 1,3-Dioxan-2-one, 31852-84-3, MFCD00010440, 2534-03-4, [1,3]dioxan-2-one, 1,3-propanediol carbonate, SCHEMBL29060, SCHEMBL3698345, SCHEMBL3705478, SCHEMBL6556330, DTXSID20953766, AKOS006282041, AB89903, FD62735, AS-10263, DB-291064, DB-321826, CS-0155207, D3821, F20507, Q161506, InChI=1/C4H6O3/c5-4-6-2-1-3-7-4/h1-3H

Application

Trimethylene Carbonate is primarily used as a monomer for synthesizing biodegradable polycarbonates via ring-opening polymerization (ROP), particularly for medical sutures and implant coatings. Its hydrolytic degradation products are non-acidic, reducing tissue inflammation in biomedical applications. Researchers also employ TMC as a copolymer with lactides/glycolides to tailor polymer degradation rates and mechanical properties for drug-eluting stents or tissue engineering scaffolds.

Safety and Hazards

GHS Hazard Statements

• H228 (100%): Flammable solid [Danger Flammable solids]

Precautionary Statements

• P210, P240, P241, P280, and P370+P378

Hazard Classes and Categories

• Acute Tox. 4 (95.5%)
• Eye Irrit. 2 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.