Description

Trifluoromethylsulfonamide (CAS No. 421-85-2) is a high-purity fluorinated sulfonamide compound with the molecular formula CH₂F₃NO₂S and IUPAC name trifluoromethanesulfonamide. This specialized chemical is widely utilized in organic synthesis, pharmaceutical research, and materials science due to its strong electron-withdrawing properties and stability under reactive conditions. It serves as a versatile building block for the introduction of the trifluoromethylsulfonyl (CF₃SO₂-) group, enabling the synthesis of advanced intermediates, catalysts, and bioactive molecules. Available in rigorously controlled batches, our product meets stringent quality standards for researchers requiring precise reactivity and consistency. Suitable for use in nucleophilic substitution reactions, cross-coupling protocols, and as a precursor for sulfonamide-based ligands.

Properties

• CAS Number: 421-85-2
• Complexity: 161
• IUPAC Name: trifluoromethanesulfonamide
• InChI: InChI=1S/CH2F3NO2S/c2-1(3,4)8(5,6)7/h(H2,5,6,7)
• InChI Key: KAKQVSNHTBLJCH-UHFFFAOYSA-N
• Exact Mass: 148.97583397
• Molecular Formula: CH2F3NO2S
• Molecular Weight: 149.09
• SMILES: C(F)(F)(F)S(=O)(=O)N
• Topological: 68.5
• Monoisotopic Mass: 148.97583397
• Synonyms: Trifluoromethanesulfonamide, 421-85-2, Trifluoromethylsulfonamide, 1,1,1-trifluoromethanesulfonamide, Trifluoromethyl sulfonamide, Methanesulfonamide, 1,1,1-trifluoro-, DTXSID10194944, DTXCID50117435, 627-705-1, trifluoromethanesulphonamide, TRIFLUOROMETHANE SULFONAMIDE, MFCD00068714, CHEMBL67511, Triflamide, CH2F3NO2S, 1bcd, 1,1,1-Trifluoromethanesulfonamide; Trifluoromethanesulfonamide, triflimidic acid, trifluorometanesulfonamide, trifiuoromethanesulfonamide, trifiuoromethylsulphonamide, trifluoromethylsulphonamide, SCHEMBL130, perfluoromethane sulfonamide, Trifluoro-methanesulfonamide, SCHEMBL24792, SCHEMBL534156, SCHEMBL6602452, Trifluoromethanesulfonamide, 95%, CS-B0881, AC2628, BBL101971, BDBM50044311, SBB086617, STL555768, AKOS003622043, FT71515, SB66436, BP-21470, DS-11388, SY014031, DB-050868, NS00008898, T1290, EN300-96724, Q27460359

Application

Trifluoromethylsulfonamide is employed as a key reagent in the synthesis of sulfonamide derivatives for pharmaceutical applications, particularly in the development of enzyme inhibitors and receptor modulators. Its electron-deficient nature makes it valuable in catalysis and as a stabilizing group in organometallic complexes. Researchers also utilize it to construct fluorinated polymers and specialty materials with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (50%)
• Acute Tox. 4 (50%)
• Acute Tox. 3 (50%)
• Skin Irrit. 2 (50%)
• Eye Dam. 1 (50%)
• Eye Irrit. 2 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.