Description

Trifluoromethanesulfonyl chloride (CAS No. 421-83-0) is a highly reactive and versatile organofluorine compound with the molecular formula CClF₃O₂S. This clear to pale yellow liquid is widely used as a trifluoromethylating and sulfonylating agent in organic synthesis. Its strong electron-withdrawing triflyl group (-SO₂CF₃) makes it invaluable for creating sulfonamides, sulfonate esters, and other derivatives. The compound exhibits excellent thermal stability and reactivity with nucleophiles, making it ideal for peptide coupling reactions, polymerization catalysts, and pharmaceutical intermediates. Packaged under inert gas to prevent hydrolysis, our high-purity grade (≥98%) is rigorously tested by GC and NMR to ensure consistency for sensitive applications. Handle with care in a fume hood using appropriate PPE due to its corrosive nature and moisture sensitivity.

Properties

• CAS Number: 421-83-0
• Complexity: 161
• IUPAC Name: trifluoromethanesulfonyl chloride
• InChI: InChI=1S/CClF3O2S/c2-8(6,7)1(3,4)5
• InChI Key: GRGCWBWNLSTIEN-UHFFFAOYSA-N
• Exact Mass: 167.9259626
• Molecular Formula: CClF3O2S
• Molecular Weight: 168.52
• SMILES: C(F)(F)(F)S(=O)(=O)Cl
• Topological: 42.5
• Monoisotopic Mass: 167.9259626
• Physical Description: Clear light yellow liquid; Boiling point = 29-32 deg C;
• Vapor Pressure: 535.6 [mmHg]
• Synonyms: Trifluoromethanesulfonyl chloride, Trifluoromethanesulphonyl chloride, Triflyl chloride, EINECS 207-009-0, DTXSID50194943, DTXCID90117434, 207-009-0, grgcwbwnlstien-uhfffaoysa-n, un3265, 421-83-0, Methanesulfonyl chloride, trifluoro-, trifluoro-methanesulfonyl chloride, trifluoromethanesulfonylchloride, CClF3O2S, MFCD00007451, triflic chloride, Trifluoromethylsulfonyl Chloride; Trifluoromethylsulfuryl Chloride; Triflyl Chloride, TRIFLUOROMETHYLSULFONYL CHLORIDE, CF3SO2Cl, SCHEMBL21681, chloro(trifluoromethyl)sulfone, Trifluormethanesulfonylchloride, trifluormethanesulfonyl chloride, trifluorometanesulfonyl chloride, trifluoromethanesufonyl chloride, trifluoromethane sulfonylchloride, trifluoromethylsulphonyl chloride, Trifiuoromethanesulfonyl chloride, trifluoromethyl sulphonyl chloride, Trifluoromethane sulphonyl chloride, CS-B0875, BBL102190, SBB088210, STL555989, trifluoromethanesulphonic acid chloride, AKOS005063740, tris(fluoranyl)methanesulfonyl chloride, FS-4166, FT03446, 1,1,1-trifluoromethanesulfonyl chloride, BP-10786, Trifluoromethanesulfonyl chloride, >=99%, NS00042815, T1027, D92440, A825799

Application

Trifluoromethanesulfonyl chloride serves as a key reagent for introducing the triflyl group in nucleoside protection and peptide synthesis. It is extensively used in lithium battery electrolytes as an electrolyte additive to improve conductivity. The compound also acts as a precursor for superacid catalysts in polymerization reactions and finds application in the preparation of sulfonamide-based pharmaceuticals.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.