Atomfair Trifluoromethanesulfonyl chloride Triflyl chloride CClF3O2S

Description Trifluoromethanesulfonyl chloride (CAS No. 421-83-0) is a highly reactive and versatile organofluorine compound with the molecular formula CClF3O2S . This clear to pale yellow liquid is widely used as a trifluoromethylating and sulfonylating agent in organic synthesis. Its strong electron-withdrawing triflyl group ( -SO2CF3) makes it invaluable for creating sulfonamides, sulfonate esters, and other derivatives. The compound exhibits excellent thermal stability and reactivity with nucleophiles, making it ideal for peptide coupling reactions, polymerization catalysts, and pharmaceutical intermediates. Packaged under inert gas to prevent hydrolysis, our high-purity grade (??98%) is rigorously tested by GC and NMR to ensure consistency for…

Description

Trifluoromethanesulfonyl chloride (CAS No. 421-83-0) is a highly reactive and versatile organofluorine compound with the molecular formula CClF₃O₂S. This clear to pale yellow liquid is widely used as a trifluoromethylating and sulfonylating agent in organic synthesis. Its strong electron-withdrawing triflyl group (-SO₂CF₃) makes it invaluable for creating sulfonamides, sulfonate esters, and other derivatives. The compound exhibits excellent thermal stability and reactivity with nucleophiles, making it ideal for peptide coupling reactions, polymerization catalysts, and pharmaceutical intermediates. Packaged under inert gas to prevent hydrolysis, our high-purity grade (??98%) is rigorously tested by GC and NMR to ensure consistency for sensitive applications. Handle with care in a fume hood using appropriate PPE due to its corrosive nature and moisture sensitivity.

CAS No: 421-83-0
Molecular Formula: CClF3O2S
Molecular Weight: 168.52
Exact Mass: 167.9259626
Monoisotopic Mass: 167.9259626
IUPAC Name: trifluoromethanesulfonyl chloride
SMILES: C(F)(F)(F)S(=O)(=O)Cl
Synonyms: Trifluoromethanesulfonyl chloride, Trifluoromethanesulphonyl chloride, Triflyl chloride, EINECS 207-009-0, DTXSID50194943

Application

Trifluoromethanesulfonyl chloride serves as a key reagent for introducing the triflyl group in nucleoside protection and peptide synthesis. It is extensively used in lithium battery electrolytes as an electrolyte additive to improve conductivity. The compound also acts as a precursor for superacid catalysts in polymerization reactions and finds application in the preparation of sulfonamide-based pharmaceuticals.

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