Description

Trifluoromethanesulfonic acid (CAS 1493-13-6), also known as triflic acid, is a superacid with the molecular formula CHF₃O₃S. It is one of the strongest organic acids available, offering exceptional thermal and chemical stability. This colorless, hygroscopic liquid is widely used in organic synthesis, catalysis, and as a protonating agent due to its non-nucleophilic nature and high acidity (pK_a ≈ -14). Trifluoromethanesulfonic acid is highly soluble in polar solvents such as water, alcohols, and acetonitrile, making it a versatile reagent for researchers and industrial applications. Its superior performance in Friedel-Crafts alkylations, acylations, and polymerization reactions makes it indispensable in pharmaceutical, material science, and chemical manufacturing. Available in high-purity grades, this product is rigorously tested for quality assurance to meet the demands of advanced research and production processes.

Properties

• CAS Number: 1493-13-6
• Complexity: 158
• IUPAC Name: trifluoromethanesulfonic acid
• InChI: InChI=1S/CHF3O3S/c2-1(3,4)8(5,6)7/h(H,5,6,7)
• InChI Key: ITMCEJHCFYSIIV-UHFFFAOYSA-N
• Exact Mass: 149.95984955
• Molecular Formula: CHF3O3S
• Molecular Weight: 150.08
• SMILES: C(F)(F)(F)S(=O)(=O)O
• Topological: 62.8
• Monoisotopic Mass: 149.95984955
• Physical Description: Colorless hygroscopic liquid;
• Synonyms: Trifluoromethanesulfonic acid, 1493-13-6, Triflic acid, Perfluoromethanesulfonic acid, Trifluoromethanesulphonic acid, Trifluoromethane sulfonic acid, acide triflique, DTXSID2044397, CF3SO3H, EINECS 216-087-5, UNII-JE2SY203E8, CHEBI:48511, AI3-62912, Trifluormethansulfonsaeure, TRIFLIC ACID [MI], acide trifluoromethanesulfonique, DTXCID0024397, EC 216-087-5, 1,1,1-trifluoromethanesulfonic acid, Al(OTf)3, Eu(OTf)3, Cerium triflate, trifluoromethanesulfonic acid, silver (+1) salt, TFMSA cpd, As(otf)2, Methanesulfonic acid, trifluoro, Methanesulfonic acid, 1,1,1trifluoro, 2923-28-6, in(otf)3, un3265, tfmsa, METHANESULFONIC ACID, TRIFLUORO-, TfOH, Trifluoromethylsulfonic acid, HOTf, MFCD00007514, TFMS, Methanesulfonic acid, 1,1,1-trifluoro-, trifluoromethane-sulfonic acid, JE2SY203E8, triflicacid, TFS, perfluoromethane sulfonate, Trifluoromethysulfonic acid, SCHEMBL295, SCHEMBL890, trifluormethanesulfonic acid, trifluoromethansulfonic acid, trifluormethanesulphonic acid, Trifiuoromethanesulfonic acid, trifluormethane sulfonic acid, trifluoromethyl sulfonic acid, trifluoromethyl-sulfonic acid, triflouromethanesulphonic acid, trifluoro-methanesulfonic acid, trifluoromethan sulphonic acid, trifluoromethyl sulphonic acid, trifluoromethanesulphoriic acid, trifluoro-methanesulphonic acid, trifluoromethane sulphonic acid, trifluoro-methane sulfonic acid, (trifluoromethyl) sulfonic acid, SCHEMBL3950101, CHEMBL1236265, Trifluoromethanesulfonic acidTFMSA, BCP21772, CS-B0871, Tox21_302183, Trifluoromethanesulphonic acid, 99%, FD2025, SBB086683, AKOS007930288, FS-3872, FT10593, NCGC00255973-01, CAS-1493-13-6, Triflic acid;Trifluoromethanesulphonic acid, DB-007930, DB-030477, NS00004757, ST51041408, T0751, EN300-21690, Q304850, Trifluoromethanesulfonic acid, reagent grade, 98%, Trifluoromethanesulfonic acid, purum, >=98.0% (T), Methanesulfonic acid, trifluoro- (6CI,7CI,8CI,9CI), Trifluoromethanesulfonic acid, ReagentPlus(R), >=99%, F0001-0530

Application

Trifluoromethanesulfonic acid is extensively used as a catalyst in organic synthesis, particularly in esterifications, alkylations, and polymerizations. Its strong acidity and stability make it ideal for protonating weak bases and facilitating challenging chemical transformations. In the pharmaceutical industry, it serves as a key reagent for synthesizing complex molecules and intermediates. Additionally, it is employed in fuel cell research and electrochemical applications due to its high proton conductivity. Its non-nucleophilic nature ensures minimal side reactions, enhancing yield and purity in sensitive processes.

Safety and Hazards

GHS Hazard Statements

• H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264+P265, P280, P305+P351+P338, and P337+P317

Hazard Classes and Categories

• Met. Corr. 1 (92.8%)
• Acute Tox. 4 (99.5%)
• Skin Corr. 1B (100%)
• STOT SE 3 (96.8%)

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