Description

Trifluoroacetohydrazide (CAS No. 1538-08-5) is a high-purity fluorinated organic compound with the molecular formula C₂H₃F₃N₂O and IUPAC name 2,2,2-trifluoroacetohydrazide. This specialized reagent is widely utilized in synthetic organic chemistry, pharmaceutical research, and material science due to its reactive hydrazide functional group and trifluoromethyl moiety. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a white to off-white crystalline powder under inert packaging to maintain stability. Ideal for nucleophilic substitution reactions, heterocycle synthesis, and as a precursor for trifluoromethylated compounds, this chemical is handled in certified laboratories to guarantee consistency and performance. Store in a cool, dry place away from oxidizing agents and moisture to preserve its reactivity.

Properties

• CAS Number: 1538-08-5
• Complexity: 97.9
• IUPAC Name: 2,2,2-trifluoroacetohydrazide
• InChI: InChI=1S/C2H3F3N2O/c3-2(4,5)1(8)7-6/h6H2,(H,7,8)
• InChI Key: OFUCCBIWEUKISP-UHFFFAOYSA-N
• Exact Mass: 128.01974721
• Molecular Formula: C2H3F3N2O
• Molecular Weight: 128.05
• SMILES: C(=O)(C(F)(F)F)NN
• Topological: 55.1
• Monoisotopic Mass: 128.01974721
• Synonyms: TRIFLUOROACETOHYDRAZIDE, 671-964-3, 2,2,2-trifluoroacetohydrazide, 1538-08-5, Trifluoroacetic acid hydrazide, TRIFLUOROACETYL HYDRAZIDE, MFCD00221440, NSC-23683, Acetic acid, trifluoro-, hydrazide, C2H3F3N2O, Trifluoroaceticaceticacid hydrazide, NSC23683, trifluoroacethydrazide, CF3CONHNH2, (Trifluoroacetyl)hydrazine, Y6KG7L6PLC, N-(trifluoroacetyl)hydrazine, SCHEMBL181090, trifluoro acetic acid hydrazide, SCHEMBL11268981, DTXSID10281969, XZBVOBLCPWWJRI-UHFFFAOYSA-N, CS-M0688, SBB059491, STL357424, AKOS004112227, AB04957, AS-5612, acetic acid, 2,2,2-trifluoro-, hydrazide, DB-064001, ST51044466, EN300-67056

Application

Trifluoroacetohydrazide serves as a versatile building block in the synthesis of trifluoromethyl-substituted heterocycles, such as pyrazoles and triazoles, which are valuable in medicinal chemistry. It is employed in the preparation of agrochemicals and pharmaceuticals due to its ability to introduce the metabolically stable trifluoromethyl group. Researchers also use it as a derivatization agent for carbonyl compounds in analytical chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.