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Atomfair Trifluoroacetic acid TFA C2HF3O2

Description Trifluoroacetic Acid (TFA) is a highly versatile and widely used fluorinated organic compound with the molecular formula C2HF3O2and CAS number 2966-50-9 . This colorless, corrosive liquid is characterized by its strong acidity (pKa ~0.23) and excellent solvating properties, making it indispensable in organic synthesis, peptide chemistry, and analytical applications. With a boiling point of 72.4??C and density of 1.489 g/cm3, TFA is miscible with water and most organic solvents. Its trifluoromethyl group confers unique electronic properties, enhancing its utility as a reagent and catalyst in numerous transformations. Packaged in high-purity form (typically ??99%), our TFA is rigorously tested for…

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Description

Description

Trifluoroacetic Acid (TFA) is a highly versatile and widely used fluorinated organic compound with the molecular formula C2HF3O2 and CAS number 2966-50-9. This colorless, corrosive liquid is characterized by its strong acidity (pKa ~0.23) and excellent solvating properties, making it indispensable in organic synthesis, peptide chemistry, and analytical applications. With a boiling point of 72.4??C and density of 1.489 g/cm3, TFA is miscible with water and most organic solvents. Its trifluoromethyl group confers unique electronic properties, enhancing its utility as a reagent and catalyst in numerous transformations. Packaged in high-purity form (typically ??99%), our TFA is rigorously tested for trace metals and water content to ensure optimal performance in sensitive applications.

Key Features:

  • High-purity grade (??99%) for demanding synthetic applications
  • Excellent solvent for peptides, proteins, and complex organic molecules
  • Powerful acid catalyst for esterifications, deprotections, and condensations
  • Critical reagent in HPLC mobile phases for improved separations
  • Available in secure, chemically resistant packaging with multiple size options
  • CAS No: 2966-50-9
  • Molecular Formula: C2HF3O2
  • Molecular Weight: 114.02
  • Exact Mass: 113.99286376
  • Monoisotopic Mass: 113.99286376
  • IUPAC Name: 2,2,2-trifluoroacetic acid
  • SMILES: C(=O)(C(F)(F)F)O
  • Synonyms: Trifluoroacetic acid, 76-05-1, Perfluoroacetic acid, Trifluoroethanoic acid, Trifluoracetic acid

Application

Trifluoroacetic acid serves as a crucial reagent in peptide synthesis, where it is used for both Boc-group deprotection and resin cleavage. In organic chemistry, TFA acts as a strong acid catalyst for various transformations including esterifications, rearrangements, and condensations. The compound finds significant use in HPLC as a mobile phase modifier for improving peak resolution, particularly in the analysis of basic compounds. Its solvating properties make it valuable for dissolving poorly soluble compounds in both analytical and preparative applications.

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