Description

Trifluoroacetamidine (CAS: 354-37-0) is a highly specialized organic compound with the molecular formula C₂H₃F₃N₂. This reagent is a trifluoromethyl-substituted acetamidine derivative, offering unique reactivity due to the electron-withdrawing nature of the trifluoromethyl group. It is widely utilized in synthetic chemistry, particularly in the preparation of heterocyclic compounds, pharmaceuticals, and agrochemical intermediates. Available in high purity grades (≥95%), this product is rigorously tested for consistency and performance, making it ideal for research and industrial applications. Packaged under inert conditions to ensure stability, Trifluoroacetamidine is a valuable building block for nucleophilic addition reactions, ligand synthesis, and catalytic processes.

Properties

• CAS Number: 354-37-0
• Complexity: 83.4
• IUPAC Name: 2,2,2-trifluoroacetamidine
• InChI: InChI=1S/C2H3F3N2/c3-2(4,5)1(6)7/h(H3,6,7)
• InChI Key: NITMACBPVVUGOJ-UHFFFAOYSA-N
• Exact Mass: 112.02483259
• Molecular Formula: C2H3F3N2
• Molecular Weight: 112.05
• SMILES: C(=N)(C(F)(F)F)N
• Topological: 49.9
• Monoisotopic Mass: 112.02483259
• Synonyms: Trifluoroacetamidine, 354-37-0, DTXSID30380286, DTXCID10331312, 670-531-6, nitmacbpvvugoj-uhfffaoysa-n, 2,2,2-trifluoroethanimidamide, trifluoroethanimidamide, 2,2,2-trifluoroacetimidamide, MFCD00041545, 2,2,2-trifluoroacetamidine, Ethanimidamide, 2,2,2-trifluoro-, Trifluoroacetamidine, tech., trifluoroacetoamidine, trifluoro-acetamidine, TRIFLUORO ACETAMIDINE, 2,2,2-trifluoroacetoamidine, 2,2,2-trifluoroethanamidine, 2,2,2-trifluoro-acetamidine, SCHEMBL233273, 2,2,2-trifluoroethaneimidamide, Trifluoroacetamidine, AldrichCPR, STR05534, 2,2,2-tris(fluoranyl)ethanimidamide, BBL100271, SBB028191, STL553837, AKOS005207237, FT77324, PB47810, BP-10869, DB-000431, EN300-44257, D94783, A822801

Trifluoroacetamidine serves as a versatile intermediate in organic synthesis, particularly for constructing nitrogen-containing heterocycles. It is employed in pharmaceutical research for developing bioactive molecules due to its trifluoromethyl group’s metabolic stability. Additionally, this compound finds use in agrochemical synthesis and material science applications where fluorinated compounds enhance performance.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (81.2%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (81.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H332 (81.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (83.3%)
• Acute Tox. 4 (81.2%)
• Skin Corr. 1 (100%)
• Acute Tox. 4 (81.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.