Description

Trifluoroacetamide (CAS No. 354-38-1) is a high-purity fluorinated organic compound with the molecular formula C₂H₂F₃NO and IUPAC name 2,2,2-trifluoroacetamide. This specialized reagent is widely utilized in synthetic chemistry, pharmaceutical research, and material science due to its unique trifluoromethyl group, which enhances reactivity and stability in various reactions. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for precise applications such as peptide synthesis, derivatization, and as a precursor for fluorinated compounds. Packaged under inert conditions to maintain integrity, Trifluoroacetamide is available in quantities ranging from grams to kilograms, with custom packaging options available upon request. Suitable for use in HPLC, NMR, and other analytical techniques.

Properties

• CAS Number: 354-38-1
• Complexity: 85.4
• IUPAC Name: 2,2,2-trifluoroacetamide
• InChI: InChI=1S/C2H2F3NO/c3-2(4,5)1(6)7/h(H2,6,7)
• InChI Key: NRKYWOKHZRQRJR-UHFFFAOYSA-N
• Exact Mass: 113.00884817
• Molecular Formula: C2H2F3NO
• Molecular Weight: 113.04
• SMILES: C(=O)(C(F)(F)F)N
• Topological: 43.1
• Monoisotopic Mass: 113.00884817
• Physical Description: White to light yellow crystalline powder with a slight ether-like odor;
• Vapor Pressure: 1.85 [mmHg]
• Synonyms: Trifluoroacetamide, 2,2,2-Trifluoroacetamide, Acetamide, 2,2,2-trifluoro-, UNII-36MU16BYFK, 2,2,2-Trifluoro-acetamide, 36MU16BYFK, NSC 9449, NSC-9449, CF3CONH2, EINECS 206-559-9, AI3-52681, DTXSID1059868, EC 206-559-9, Acetamide, 2,2,2trifluoro, DTXCID0039011, nrkywokhzrqrjr-uhfffaoysa-n, 354-38-1, MFCD00008008, trifluoroacetic acid amide, C2H2F3NO, N-trifluoroacetamide, trifluroacetamide, trifluoro-acetamide, 2,2-Trifluoroacetamide, Trifluoroacetamide, 97%, SCHEMBL141, SCHEMBL142, 2,2,2 trifluoroacetamide, 2,2,2-trifluoro acetamide, CHEMBL117012, SCHEMBL3647108, NSC9449, YCLITVUUQICKAU-UHFFFAOYSA-N, BBL027671, BDBM50226184, STL146458, AKOS005207149, CS-W018487, FT46948, DB-048810, NS00009326, T0598, EN300-19421, D71062, Q27256578, F0001-1023

Application

Trifluoroacetamide is commonly employed as a versatile building block in organic synthesis, particularly in the preparation of fluorinated pharmaceuticals and agrochemicals. It serves as a key intermediate in the synthesis of trifluoroacetyl-protected amines and peptides, enhancing stability during complex reactions. Researchers also utilize it in derivatization protocols for GC-MS analysis due to its excellent volatility and detection sensitivity. Additionally, its electron-withdrawing properties make it valuable in material science for modifying polymer properties.

Safety and Hazards

GHS Hazard Statements

• H302 (27.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (27.8%)
• Skin Irrit. 2 (98.7%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.