Description

Trifluoroacetaldehyde Hydrate (CAS No. 421-53-4) is a highly versatile fluorinated organic compound with the molecular formula C₂H₃F₃O₂. This reagent is commonly supplied as a technical-grade solution (~75% in water), making it an essential building block for synthetic organic chemistry and pharmaceutical applications. Its unique trifluoromethyl group enhances reactivity and stability, making it ideal for nucleophilic addition reactions, trifluoromethylation processes, and as a precursor for fluorinated heterocycles. Suitable for use in controlled laboratory environments, this compound is handled under strict safety protocols due to its moisture sensitivity. Store in a cool, dry place under inert gas to prevent degradation.

Properties

• CAS Number: 421-53-4
• Complexity: 56.4
• IUPAC Name: 2,2,2-trifluoroethane-1,1-diol
• InChI: InChI=1S/C2H3F3O2/c3-2(4,5)1(6)7/h1,6-7H
• InChI Key: VGJWVEYTYIBXIA-UHFFFAOYSA-N
• Exact Mass: 116.00851382
• Molecular Formula: C2H3F3O2
• Molecular Weight: 116.04
• SMILES: C(C(F)(F)F)(O)O
• Topological: 40.5
• Monoisotopic Mass: 116.00851382
• Synonyms: Trifluoroacetaldehyde hydrate, 421-53-4, Fluoral hydrate, 1,1-Ethanediol, 2,2,2-trifluoro-, Fluoral, hydrate, 2,2,2-Trifluoro-1,1-ethanediol, Acetaldehyde, trifluoro-, hydrate, EINECS 207-006-4, NSC 146025, BRN 1736686, DTXSID4059964, DTXCID1040033, 4-01-00-03133 (beilstein handbook reference), 2,2,2-trifluoroethane-1,1-diol, Tfaih, Trifluoroacetaldehyde hydrate, tech., ca 75% in water, NSC-146025, 2,2,2-Trifluoroethanediol, 2,2,2-Trifluoro-1,1-ethanediol (contains Total ca. 35% Water), Trifluoroacetaldehyde hydrate (tech.), Acetaldehyde, hydrate, Trifluoroethanal hydrate, WLN: QYQXFFF, Trifluoracetaldehyd-hydrat, WLN: VHXFFF &QH, 1, 2,2,2-trifluoro-, DWG4394PJH, SCHEMBL27245, SCHEMBL27246, Trifluoroacetaldehyde, solution, SCHEMBL8006322, 2,2-Trifluoro-1,1-ethanediol, SCHEMBL28158356, 2,2-Trifluoroacetaldehyde hydrate, BCP05623, BBL101718, NSC146025, STL555515, AKOS002662632, DB-050862, Trifluoroacetaldehyde hydrate (diol), tech., CS-0332345, NS00043802, T3654, 2,2,2-Trifluoro-1,1-ethanediol (contains Total ca. 25% Water)

Trifluoroacetaldehyde Hydrate is widely used as a trifluoromethylating agent in pharmaceutical synthesis and agrochemical research. It serves as a key intermediate in the preparation of fluorinated analogs of biologically active molecules. The compound is also employed in materials science for modifying polymer properties and in catalysis for asymmetric synthesis. Its reactivity with nucleophiles makes it valuable for constructing complex fluorinated scaffolds.

Safety and Hazards

GHS Hazard Statements

• H225 (86.7%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H302 (95.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (88.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (86.7%)
• Acute Tox. 4 (95.6%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2 (88.9%)
• STOT SE 3 (97.8%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.