Description

(Tetrahydrofuran-3-yl)methanamine (CAS No. 165253-31-6) is a high-purity organic compound with the molecular formula C₅H₁₁NO. This versatile amine derivative features a tetrahydrofuran (THF) ring with an aminomethyl substituent at the 3-position, making it a valuable building block in pharmaceutical and chemical synthesis. Its IUPAC name, oxolan-3-ylmethanamine, reflects its structural characteristics. This compound is supplied as a clear, colorless to pale yellow liquid with a characteristic amine odor, suitable for research and industrial applications. It is ideal for use in nucleophilic reactions, reductive aminations, and as a precursor for heterocyclic compounds. Strict quality control ensures high purity (typically ≥95% by GC) for reliable performance in synthetic workflows. Store under inert atmosphere at 2-8°C to maintain stability.

Properties

• CAS Number: 165253-31-6
• Complexity: 56
• IUPAC Name: tetrahydrofuran-3-ylmethanamine
• InChI: InChI=1S/C5H11NO/c6-3-5-1-2-7-4-5/h5H,1-4,6H2
• InChI Key: CINJIXGRSTYIHP-UHFFFAOYSA-N
• Exact Mass: 101.084063974
• Molecular Formula: C5H11NO
• Molecular Weight: 101.15
• SMILES: C1COCC1CN
• Topological: 35.3
• Monoisotopic Mass: 101.084063974
• Synonyms: (tetrahydrofuran-3-yl)methanamine, DTXSID30447520, DTXCID30398341, 165253-31-6, Oxolan-3-ylmethanamine, 3-furanmethanamine, tetrahydro-, 1-tetrahydrofuran-3-ylmethanamine, 3-(Aminomethyl)tetrahydrofuran, c-(tetrahydro-furan-3-yl)-methylamine, tetrahydrofuran-3-ylmethylamine, C-(Tetrahydrofuran-3-yl)methylamine, (oxolan-3-yl)methanamine, TETRAHYDRO-3-FURANMETHANAMINE, MFCD08234925, MFCD17015963, MFCD17015964, 3-tetrahydrofurylmethylamine, Tetrahydrofuran-3-methanamine, SCHEMBL470130, 3-Furanmethanamine,tetrahydro-, SCHEMBL3114809, SCHEMBL3144903, [(3-tetrahydrofuryl)methyl]amine, CINJIXGRSTYIHP-UHFFFAOYSA-N, (R)-Tetrahydrofuran-3-methanamine, (S)-Tetrahydrofuran-3-methanamine, 3-(Aminomethyl)tetrahydrofuran, 95%, AKOS002434710, AKOS016344365, CS-W004787, PB10526, PB18204, SB10339, [(3R)-Tetrahydrofuran-3-yl]methanamine, [(3S)-Tetrahydrofuran-3-yl]methanamine, BS-12693, Racemic (tetrahydrofuran-3-yl)methanamine, SY042027, SY098654, SY098675, DB-064571, A3239, NS00007203, EN300-31754, F8881-1090, Z239627334

Application

(Tetrahydrofuran-3-yl)methanamine serves as a key intermediate in medicinal chemistry for the development of bioactive molecules targeting neurological disorders. Its structural motif is utilized in the synthesis of protease inhibitors and GPCR modulators. The compound’s bifunctional reactivity enables conjugation with carboxylic acids or carbonyl compounds for scaffold diversification. Researchers also employ it in asymmetric catalysis as a chiral auxiliary. Its THF ring enhances solubility in organic matrices for formulation studies.

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