Description

Tetrabutylammonium hydrogen sulfate (CAS No. 32503-27-8) is a high-purity quaternary ammonium salt with the molecular formula C₁₆H₃₇NO₄S. This white to off-white crystalline powder is widely utilized in organic synthesis, catalysis, and phase-transfer reactions due to its excellent solubility in polar solvents such as water, methanol, and acetonitrile. With a molecular weight of 339.53 g/mol, it serves as a robust phase-transfer catalyst (PTC) in alkylation, oxidation, and polymerization reactions. Its high thermal stability and low hygroscopicity make it ideal for laboratory and industrial applications. Packaged under inert conditions to ensure longevity, this reagent is a must-have for researchers in pharmaceuticals, material science, and electrochemistry.

Properties

• CAS Number: 32503-27-8
• Complexity: 192
• IUPAC Name: hydrogen sulfate;tetrabutylammonium
• InChI: InChI=1S/C16H36N.H2O4S/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;1-5(2,3)4/h5-16H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1
• InChI Key: SHFJWMWCIHQNCP-UHFFFAOYSA-M
• Exact Mass: 339.24432984
• Molecular Formula: C16H37NO4S
• Molecular Weight: 339.5
• SMILES: CCCC[N+](CCCC)(CCCC)CCCC.OS(=O)(=O)[O-]
• Topological: 85.8
• Monoisotopic Mass: 339.24432984
• Physical Description: White crystalline powder; Hygroscopic;
• Synonyms: 32503-27-8, Tetrabutylammonium hydrogen sulfate, Tetrabutylammonium hydrogen sulphate, 1-Butanaminium, N,N,N-tributyl-, sulfate (1:1), EINECS 251-068-5, Tetranbutylammonium hydrogen sulfate, 1Butanaminium, N,N,Ntributyl, sulfate (1:1), 251-068-5, Tetrabutylammonium hydrogensulfate, tetra-n-Butylammonium hydrogen sulfate, Tetrabutylammonium bisulfate, Tetrabutylammonium sulfate (1:1), tetrabutylazanium hydrogen sulfate, tetrabutyl-ammonium hydrogensulfate, tetrabutyl ammonium hydrogen sulfate, tetrabutylammonium hydrosulfate, TBAHS, hydrogen sulfate,tetrabutylazanium, MFCD00011637, TETRABUTYLAMMONIUMHYDROGENSULFATE, hydrogen sulfate;tetrabutylazanium, Tetrabutylammonium (hydrogensulfate), tetra-n-butylammonium hydrogensulfate, Tetrabutyl-ammonium hydrogen sulfate, Tetrabutyl ammonium bisulfate, C16H37NO4S, n,n,n-tributyl-1-butanaminiumhydrogen sulfate, tetrabutylammonium hydrogensulphate, nBu4NHSO4, tetra-n-butyl ammonium hydrogen sulfate, Bu4NHSO4, n-Bu4NHSO4, IPC-TBA-HS, KCU8DU7VEL, (nBu)4NHSO4, tetrabutylammoniumbisulfate, (n-Bu)4NHSO4, (Bu)4NHSO4, tetrabutylammonium bisulphate, SCHEMBL24419, tetrabutyl ammonium bisulphate, tetra n butylammonium bisulfate, tetra n-butylammonium bisulfate, tetra-n butylammonium bisulfate, tetra-n-butylammonium bisulfate, tetra-n-butylammonium bisulphate, tetrabutylamonium hydrogensulfate, CHEMBL1079247, DTXSID4067690, SCHEMBL18044437, tetra(n-butyl)ammonium bisulfate, tetra-n-butyl ammonium bisulfate, tetrabutyl-ammoniumhydrogensulfate, tetrabutylammoniumhydrogen sulfate, tetrabutylammoniumhydrogensulphate, tetrabutylamonium hydrogensulphate, tetra-n-butyl ammonium bisulphate, tetrabutylamonium hydrogen sulfate, tetrabuthylammonium hydrogensulfate, tetrabutylammoniumhydrogen sulphate, tetra-butylammonium hydrogensulfate, tetrabutyl ammonium hydrogensulfate, tetra-butylammonium hydrogensulphate, BCP24462, HY-Y1045, STR02186, tetra-butylammonium hydrogen sulfate, tetra-n-butylammonium hydrogensulfat, tetrabutyl-ammonium hydrogen-sulfate, hydrogensulfate tetra n-butylammonium, tetra n-butylammonium hydrogensulfate, tetra-n-butyl-ammoniumhydrogensulfate, Tetrabutyl ammonium hydrogen sulphate, tetrabutyl-ammonium hydrogen sulphate, tetrabutyl-ammonium hydrogen-sulphate, tetran-butylammonium hydrogen sulfate, MSK002120, SBB061503, tetra-butyl-ammonium hydrogen sulfate, tetra n-butyl ammonium hydrogensulfate, tetra n-butylammonium hydrogen sulfate, tetra n-butylammonium hydrogensulphate, tetra-n-butyl ammonium hydrogensulfate, tetra-n-butylammonium hydrogensulphate, AKOS015892722, tetra-n-butylammonium hydrogen sulphate, CS-W019970, FT28066, tetra-n -butylammonium hydrogen sulfate, tetrabutylammonium hydrogen sulfate salt, Ammonium, tetrabutyl-, sulfate (1:1), tetra-n-butyl ammonium hydrogen sulphate, tetra-n-butyl-ammonium hydrogen sulphate, Tetrabutylammonium hydrogensulfate; TBAHS, SY001880, DB-050391, I0368, ST51047506, T0835, TETRA BUTYL AMMONIUM HYDROGEN SULPHATE, EN300-35958, D70413, Tetrabutylammonium bisulfate solution, 55% in H2O, F0001-0966, Tetrabutylammonium hydrogen sulfate, for ion pair chromatography for HPLC, Tetrabutylammonium hydrogensulfate [Reagent for Ion-Pair Chromatography], N,N,N-Tributyl-1-butanaminium sulfate;Tetrabutyl-ammonium sulfate;Tetrabutylammonium hydrogen sulfate

Application

Tetrabutylammonium hydrogen sulfate is extensively used as a phase-transfer catalyst in organic synthesis, facilitating reactions between immiscible reactants. It plays a key role in the alkylation of phenols, carboxylates, and sulfonamides under mild conditions. Additionally, it is employed in electrochemical applications, including the preparation of ionic liquids and conductive polymers. Its stability and efficiency make it valuable in industrial-scale chemical manufacturing.

Safety and Hazards

GHS Hazard Statements

• H302 (90.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (26%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (70.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (24.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (73.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (51.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (24.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.9%)
• Skin Corr. 1C (26%)
• Skin Irrit. 2 (70.1%)
• Eye Dam. 1 (24.2%)
• Eye Irrit. 2 (73.6%)
• STOT SE 3 (51.5%)
• Aquatic Chronic 3 (24.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.