Description

tert-butyl N-(4-fluoropyridin-2-yl)carbamate (CAS No. 1237535-76-0) is a high-purity organic compound with the molecular formula C₁₀H₁₃FN₂O₂. This specialized carbamate derivative features a tert-butyl group and a fluoropyridinyl moiety, making it a valuable intermediate in pharmaceutical and agrochemical research. With a molecular weight of 212.22 g/mol, it is characterized by its stability and reactivity in synthetic applications. This product is rigorously tested for quality, ensuring ≥95% purity (HPLC) and compliance with industry standards. Ideal for use in cross-coupling reactions, peptide synthesis, and as a building block for bioactive molecules, it is supplied in sealed packaging under inert conditions to maintain integrity.

Properties

• CAS Number: 1237535-76-0
• Complexity: 228
• IUPAC Name: tert-butyl N-(4-fluoro-2-pyridyl)carbamate
• InChI: InChI=1S/C10H13FN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14)
• InChI Key: VIUIAFNUKMJWFD-UHFFFAOYSA-N
• Exact Mass: 212.09610582
• Molecular Formula: C10H13FN2O2
• Molecular Weight: 212.22
• SMILES: CC(C)(C)OC(=O)NC1=NC=CC(=C1)F
• Topological: 51.2
• Monoisotopic Mass: 212.09610582
• Synonyms: 1237535-76-0, tert-butyl N-(4-fluoropyridin-2-yl)carbamate, 817-133-2, tert-butyl 4-fluoropyridin-2-ylcarbamate, tert-butyl (4-fluoropyridin-2-yl)carbamate, (4-FLUORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER, MFCD21362361, tert-butyl(4-fluoropyridin-2-yl)carbamate, SCHEMBL2029613, N-Boc-4-fluoropyridin-2-amine, 2-(Boc-amino)-4-fluoropyridine, VIUIAFNUKMJWFD-UHFFFAOYSA-N, MZB53576, AKOS027254190, SB21227, AS-64620, DA-46883, SY124536, CS-0036406, EN300-268805, Z1508687701

Application

tert-butyl N-(4-fluoropyridin-2-yl)carbamate is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and antiviral agents. Its fluoropyridine scaffold enhances binding affinity in drug-receptor interactions, making it valuable for medicinal chemistry. Researchers also employ it in peptide coupling reactions and as a protecting group in organic synthesis. The compound’s stability under acidic conditions further expands its utility in multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.