Description

tert-Butyl indoline-1-carboxylate (CAS No. 143262-10-6) is a high-purity organic compound with the molecular formula C₁₃H₁₇NO₂. This derivative of indoline features a tert-butyl carbamate group, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. Its IUPAC name, tert-butyl 2,3-dihydroindole-1-carboxylate, reflects its structural precision. The compound is supplied as a crystalline solid with ≥95% purity (HPLC), ensuring consistency for research and industrial applications. Ideal for use in N-protection strategies, cross-coupling reactions, and heterocyclic chemistry, it is packaged under inert gas to maintain stability. Available in quantities from grams to kilograms, with custom synthesis options upon request.

Properties

• CAS Number: 143262-10-6
• Complexity: 270
• IUPAC Name: tert-butyl indoline-1-carboxylate
• InChI: InChI=1S/C13H17NO2/c1-13(2,3)16-12(15)14-9-8-10-6-4-5-7-11(10)14/h4-7H,8-9H2,1-3H3
• InChI Key: GWAXLDLPPZPQLO-UHFFFAOYSA-N
• Exact Mass: 219.125928785
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.28
• SMILES: CC(C)(C)OC(=O)N1CCC2=CC=CC=C21
• Topological: 29.5
• Monoisotopic Mass: 219.125928785
• Synonyms: 143262-10-6, tert-Butyl indoline-1-carboxylate, DTXSID30394808, DTXCID80345668, 623-971-8, 1-BOC-INDOLINE, Tert-butyl 2,3-dihydroindole-1-carboxylate, 1H-Indole-1-carboxylic acid, 2,3-dihydro-, 1,1-dimethylethyl ester, tert-butyl indolinecarboxylate, tert-butyl 1-indolinecarboxylate, MFCD01318399, 1-t-butyloxycarbonylindoline, N-(t-butoxycarbonyl)indoline, SCHEMBL552069, SCHEMBL3459528, SCHEMBL20914962, SCHEMBL26609193, SCHEMBL27739868, tert-Butylindoline-1-carboxylate, GWAXLDLPPZPQLO-UHFFFAOYSA-, GWAXLDLPPZPQLO-UHFFFAOYSA-N, TFA26210, SBB095804, AKOS009158345, SB64104, tert-Butyl indoline-1-carboxylate, 98%, CS-0082136, ST50825697, EN300-127043, F17563, tert-butyl 2,3-dihydro-1H-indole-1-carboxylate, A838402, 2,3-dihydroindole-1-carboxylic acid tert-butyl ester, 1,1-dimethylethyl 2,3-dihydro-1H-indole-1-carboxylate, 2,3-dihydro-1H-indole-1-carboxylic acid tert-butyl ester, InChI=1/C13H17NO2/c1-13(2,3)16-12(15)14-9-8-10-6-4-5-7-11(10)14/h4-7H,8-9H2,1-3H3

Application

tert-Butyl indoline-1-carboxylate serves as a key building block in medicinal chemistry for the synthesis of indoline-based drug candidates. It is widely used as a protective group for nitrogen in peptide and heterocycle synthesis. The compound also finds applications in catalytic asymmetric hydrogenation studies and as a precursor for functionalized indoles. Researchers leverage its stability in multi-step organic transformations to develop novel bioactive molecules.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.