Atomfair tert-butyl (5R)-5-amino-3,3-difluoropiperidine-1-carboxylate C10H18F2N2O2 CAS 1392473-32-3

Description

tert-butyl (5R)-5-amino-3,3-difluoropiperidine-1-carboxylate (CAS No. 1392473-32-3) is a high-purity, enantiomerically pure chiral building block designed for advanced pharmaceutical and chemical research applications. With the molecular formula C₁₀H₁₈F₂N₂O₂, this compound features a Boc-protected amino group and two fluorine atoms at the 3-position of the piperidine ring, offering unique reactivity and stability for synthetic modifications. Ideal for medicinal chemistry, drug discovery, and process development, this reagent is rigorously tested to ensure ≥98% purity (HPLC) and meets stringent quality standards. Packaged under inert conditions to maintain integrity, it is a valuable tool for researchers seeking to develop novel bioactive molecules or optimize synthetic pathways.

Properties

• CAS Number: 1392473-32-3
• Complexity: 276
• IUPAC Name: tert-butyl (5R)-5-amino-3,3-difluoro-piperidine-1-carboxylate
• InChI: InChI=1S/C10H18F2N2O2/c1-9(2,3)16-8(15)14-5-7(13)4-10(11,12)6-14/h7H,4-6,13H2,1-3H3/t7-/m1/s1
• InChI Key: YHFQRFDPXSAJPK-SSDOTTSWSA-N
• Exact Mass: 236.13363415
• Molecular Formula: C10H18F2N2O2
• Molecular Weight: 236.26
• SMILES: CC(C)(C)OC(=O)N1C[C@@H](CC(C1)(F)F)N
• Topological: 55.6
• Monoisotopic Mass: 236.13363415
• Synonyms: tert-butyl (5R)-5-amino-3,3-difluoropiperidine-1-carboxylate, 1392473-32-3, (R)-tert-Butyl 5-amino-3,3-difluoropiperidine-1-carboxylate, MFCD28004346, SCHEMBL23807876, YHFQRFDPXSAJPK-SSDOTTSWSA-N, tert-butyl(5R)-5-amino-3,3-difluoropiperidine-1-carboxylate, AKOS037644588, AS-54039, CS-0048511, (5R)-1-Boc-5-amino-3,3-difluoropiperidine, P17430, t-Butyl (5R)-5-amino-3,3-difluoropiperidine-1-carboxylate

This compound serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and CNS-targeting drugs. Its chiral (R)-configuration and difluorinated piperidine core make it ideal for structure-activity relationship (SAR) studies. Researchers also utilize it in peptide mimetics and as a scaffold for PET tracer development due to the fluorine atoms’ isotopic labeling potential. Handle under inert conditions to preserve stability.

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