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Atomfair tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate 1-Boc-pyrazole-4-boronic acid pinacol ester C14H23BN2O4

Description tert-Butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate (CAS: 552846-17-0) is a high-purity boronic ester derivative extensively utilized in organic synthesis and pharmaceutical research. With the molecular formula C14H23BN2O4, this compound features a pinacol boronate ester group coupled with a Boc-protected pyrazole moiety, offering excellent stability and reactivity for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate , reflects its precise chemical structure. Ideal for researchers, this product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure ??95% purity, making it a reliable building block for drug discovery, agrochemical development, and materials science applications. Packaged under inert gas to prevent degradation.

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Description

Description

tert-Butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate (CAS: 552846-17-0) is a high-purity boronic ester derivative extensively utilized in organic synthesis and pharmaceutical research. With the molecular formula C14H23BN2O4, this compound features a pinacol boronate ester group coupled with a Boc-protected pyrazole moiety, offering excellent stability and reactivity for Suzuki-Miyaura cross-coupling reactions. Its IUPAC name, tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate, reflects its precise chemical structure. Ideal for researchers, this product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure ??95% purity, making it a reliable building block for drug discovery, agrochemical development, and materials science applications. Packaged under inert gas to prevent degradation.

  • CAS No: 552846-17-0
  • Molecular Formula: C14H23BN2O4
  • Molecular Weight: 294.16
  • Exact Mass: 294.1750874
  • Monoisotopic Mass: 294.1750874
  • IUPAC Name: tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN(N=C2)C(=O)OC(C)(C)C
  • Synonyms: tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate, 676-377-6, 552846-17-0, 1-Boc-pyrazole-4-boronic acid pinacol ester, tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

Application

This compound serves as a versatile intermediate in Pd-catalyzed cross-coupling reactions, enabling the synthesis of biaryl and heteroaryl structures prevalent in pharmaceuticals. It is particularly valuable in constructing pyrazole-based scaffolds for kinase inhibitors and anticancer agents. The Boc-protecting group enhances solubility and facilitates further functionalization under mild conditions. Researchers also employ it in high-throughput screening and proteomics due to its robust stability.

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