Description

Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (CAS No. 211108-50-8) is a high-purity fluorinated piperidine derivative widely used in pharmaceutical and organic synthesis research. This compound, with the molecular formula C₁₀H₁₆FNO₃, features a reactive 4-oxo group and a fluorine substituent at the 3-position, making it a versatile intermediate for the development of bioactive molecules and drug candidates. The tert-butyloxycarbonyl (Boc) protecting group enhances its stability during synthetic transformations. Suitable for nucleophilic substitutions, carbonyl chemistry, and heterocycle functionalization, this reagent is rigorously tested for quality (HPLC, NMR) and supplied in sealed packaging to ensure optimal performance. Ideal for medicinal chemists and researchers exploring fluorinated scaffolds.

Properties

• CAS Number: 211108-50-8
• Complexity: 272
• IUPAC Name: tert-butyl 3-fluoro-4-oxo-piperidine-1-carboxylate
• InChI: InChI=1S/C10H16FNO3/c1-10(2,3)15-9(14)12-5-4-8(13)7(11)6-12/h7H,4-6H2,1-3H3
• InChI Key: JZNWQLLPLOQGOI-UHFFFAOYSA-N
• Exact Mass: 217.11142153
• Molecular Formula: C10H16FNO3
• Molecular Weight: 217.24
• SMILES: CC(C)(C)OC(=O)N1CCC(=O)C(C1)F
• Topological: 46.6
• Monoisotopic Mass: 217.11142153
• Synonyms: 211108-50-8, TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE, DTXSID00441752, DTXCID00392573, 694-808-6, 1-BOC-3-FLUORO-4-OXOPIPERIDINE, 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-OXO-, 1,1-DIMETHYLETHYL ESTER, 3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester, MFCD10566554, C10H16FNO3, 3-Fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester, tert-butyl 3-fluoro-4-oxo-1-piperidinecarboxylate, MFCD28010938, MFCD30182149, (S)-tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone, tert-butyl3-fluoro-4-oxopiperidine-1-carboxylate, tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate, N-Boc-5-fluoro-4-piperidone, SCHEMBL255933, N-Boc-3-fluoro-4-piperidinone, JZNWQLLPLOQGOI-UHFFFAOYSA-N, BCP07877, BBL102671, STL556475, (R)-1-Boc-3-fluoropiperidin-4-one, (S)-1-Boc-3-fluoro-4-oxopiperidine, 1-BOC-3-FLUORO-4-PIPERIDONE, AKOS005145774, AC-8858, CS-W000521, PB13258, SB12772, SB21990, SS-4324, 1-Boc-3-fluoro-4-oxopiperidine, 95%, SY015075, SY099047, SY344620, DB-013013, 1-tert-butoxycarbonyl-3-fluoro-4-piperidone, B4858, A26037, EN300-170891, AU-004/43508333, (+/-)-tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate, 3-Fluoro-4-oxo-1-piperidinecarboxylic Acid tert-Butyl Ester, tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate, AldrichCPR, 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one;1-Boc-3-fluoro-4-piperidone

Application

Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of CNS-targeting drugs and enzyme inhibitors. Its reactive keto group enables further derivatization via reductive amination or Grignard reactions, while the fluorine atom can modulate metabolic stability. Researchers also employ it in fragment-based drug design and as a precursor for PET radiotracer candidates.

Safety and Hazards

GHS Hazard Statements

• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264+P265, P280, P305+P351+P338, and P337+P317

Hazard Classes and Categories

• Eye Irrit. 2A (100%)

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