Description

tert-Butyl 1,8-diazaspiro[4.5]decane-1-carboxylate (CAS No. 885279-92-5) is a high-purity organic compound with the molecular formula C₁₃H₂₄N₂O₂. This spirocyclic amine derivative features a tert-butyl carbamate protecting group, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. Its rigid spiro[4.5]decane scaffold provides unique steric and electronic properties for structure-activity relationship studies. Supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), this compound is ideal for medicinal chemistry applications, particularly in the development of CNS-active compounds and enzyme inhibitors. Packaged under inert gas to ensure stability, it is suitable for research use under GMP-compliant conditions.

Properties

• CAS Number: 885279-92-5
• Complexity: 290
• IUPAC Name: tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate
• InChI: InChI=1S/C13H24N2O2/c1-12(2,3)17-11(16)15-10-4-5-13(15)6-8-14-9-7-13/h14H,4-10H2,1-3H3
• InChI Key: AGYJKDRKBSJWLJ-UHFFFAOYSA-N
• Exact Mass: 240.183778013
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.34
• SMILES: CC(C)(C)OC(=O)N1CCCC12CCNCC2
• Topological: 41.6
• Monoisotopic Mass: 240.183778013
• Synonyms: 885279-92-5, tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate, DTXSID90653029, tert-Butyl 1,8-diazaspiro(4.5)decane-1-carboxylate, DTXCID20603779, 847-094-7, 1-Boc-1,8-diaza-spiro[4.5]decane, 1,8-Diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester, 1,8-Diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester, MFCD06739037, 1-Boc-1,8-diazaspiro[4.5]decane, SCHEMBL700241, AGYJKDRKBSJWLJ-UHFFFAOYSA-N, KKB27992, 1,8-Diazaspiro[4.5]decane-1-carboxylic acid, 1,1-dimethylethyl ester, AKOS015910088, PB24942, DS-11999, SY065555, CS-0000550, EN300-268908, Tert-butyl 1,8-diazaspiro[4,5]decane-1-carboxylate, Z3014353460

Application

This spirocyclic building block is widely used in medicinal chemistry for the synthesis of biologically active molecules targeting neurological disorders. Its constrained geometry makes it particularly valuable for developing sigma receptor ligands and dopamine modulators. Researchers also employ it as a key intermediate in the preparation of protease inhibitors and allosteric enzyme modulators.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.