Description

Sevoflurane (CAS No. 28523-86-6) is a fluorinated methyl isopropyl ether with the molecular formula C₄H₃F₇O. It is a highly purified, non-flammable volatile liquid anesthetic agent widely used in both human and veterinary medicine. Sevoflurane is characterized by its low blood-gas solubility, ensuring rapid induction and recovery from anesthesia. Its IUPAC name, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane, reflects its unique halogenated structure, contributing to its stability and efficacy. This pharmaceutical-grade compound is supplied in sealed amber vials or bottles under inert atmosphere to maintain purity and prevent degradation. Suitable for research in anesthesiology, pharmacokinetics, and pharmacodynamics, Sevoflurane is handled under strict GMP/ISO standards.

Properties

• CAS Number: 28523-86-6
• Complexity: 121
• IUPAC Name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane
• InChI: InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
• InChI Key: DFEYYRMXOJXZRJ-UHFFFAOYSA-N
• Exact Mass: 200.00721185
• Molecular Formula: C4H3F7O
• Molecular Weight: 200.05
• SMILES: C(OC(C(F)(F)F)C(F)(F)F)F
• Topological: 9.2
• Monoisotopic Mass: 200.00721185
• Physical Description: A clear, nonflammable colorless liquid with a non-irritating odor;
• Color/Form: Liquid
• Melting Point: < 25 °C
• Solubility: Very slightly soluble
• Density: 1505 at 25 °C/D
• Vapor Pressure: 157.0 [mmHg]
• Synonyms: sevoflurane, 28523-86-6, 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane, Sevofluran, Sevoflurano, Sojourn, MR6S4, sevoflo, Sevofluranum, Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-, Sevocalm, Petrem, fluoromethyl hexafluoroisopropyl ether, MR-6S4, NSC-760367, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether, 38LVP0K73A, CHEBI:9130, DTXSID8046614, DTXCID6026614, ETHER, FLUOROMETHYL 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL)ETHYL-, SEVOFLURANE (MART.), SEVOFLURANE [MART.], SEVOFLURANE (USP-RS), SEVOFLURANE [USP-RS], SEVOFLURANE (EP IMPURITY), SEVOFLURANE [EP IMPURITY], SEVOFLURANE (EP MONOGRAPH), SEVOFLURANE (USP IMPURITY), SEVOFLURANE [EP MONOGRAPH], SEVOFLURANE [USP IMPURITY], SEVOFLURANE (USP MONOGRAPH), SEVOFLURANE [USP MONOGRAPH], SEVOFLURANE (EMA EPAR VETERINARY), SEVOFLURANE [EMA EPAR VETERINARY], Sevospire, FlurovessTM, fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether, Sevoflurane Bostonbio, N01AB08, Fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether, fluoromethyl-1,1,1,3,3,3-hexafluoro-2-propyl ether, svf, Ultane, Sevorane, Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether, Sevofluranum [INN-Latin], Sevoflurano [INN-Spanish], 1H,1H,3H-Perfluoro(3-methyl-2-oxabutane), 1173021-96-9, MFCD00153189, NCGC00167421-01, Sevofrane, Fluoromethyl 2H-hexafluoroprop-2-yl ether, Bax 3084, Sevoflurane-d3, Fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether-d3, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether-d3, Ultane (TN), BRN 2041023, UNII-38LVP0K73A, HSDB 8059, Propane,1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-, Sevoflurane [USAN:USP:INN:BAN:JAN], SEVOFLURANE [MI], SEVOFLURANE [INN], SEVOFLURANE [JAN], F0691, SEVOFLURANE [USAN], SEVOFLURANE [VANDF], (CF3)2CHOCH2F, SCHEMBL61918, SEVOFLURANE [WHO-DD], GTPL7296, CHEMBL1200694, SEVOFLURANE [GREEN BOOK], Sevoflurane (JP18/USAN/INN), SEVOFLURANE [ORANGE BOOK], HMS3264N21, HMS5086J21, Pharmakon1600-01503680, Tox21_112425, NSC760367, SBB092545, AKOS007930500, CCG-213707, DB01236, FS29164, NSC 760367, NCGC00167421-02, AC-15484, AS-13261, CAS-28523-86-6, DB-047409, NS00014360, S2464, C07520, D00547, D78401, EN300-123016, SBI-0653442.0001, AB01563174_01, Q419394, SR-01000944968, SR-01000944968-1, BRD-K05638300-001-01-2, Z1269113624, 2,2,2-trifluoro-1-(fluoromethoxy)-1-(trifluoromethyl)ethane

Application

Sevoflurane is primarily used as an inhalation anesthetic for induction and maintenance of general anesthesia in surgical procedures. Its rapid onset and offset of action make it ideal for outpatient and pediatric surgeries. Researchers also utilize Sevoflurane to study its effects on neurotransmitter systems, organ toxicity, and neuroprotection in preclinical models. Additionally, it serves as a reference standard in analytical chemistry for method development and quality control in pharmaceutical formulations.

Safety and Hazards

GHS Hazard Statements

• H315 (44.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (45.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H336 (56.4%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H361 (53.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Precautionary Statements

• P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (44.7%)
• Eye Irrit. 2 (45.7%)
• STOT SE 3 (56.4%)
• Repr. 2 (53.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.