Description

Senna (CAS: 81-27-6) is a natural glycoside derived from the leaves and pods of the Senna plant species, widely recognized for its therapeutic laxative properties. Its molecular formula, C₄₂H₃₈O₂₀, highlights its complex anthraquinone-based structure, which includes two glucose moieties linked to a bianthracene core. This high-purity compound is meticulously processed to ensure consistency, making it ideal for pharmaceutical research, nutraceutical formulations, and clinical applications. Available in powdered or standardized extract forms, our Senna product is rigorously tested for potency (e.g., sennoside A+B content ≥90%) and contaminants (heavy metals, microbial limits) to meet USP/EP standards. Suitable for use in bulk formulations, capsules, or teas, it offers researchers a reliable, plant-derived active ingredient with well-documented stimulant laxative effects via colonic motility enhancement.

Properties

• CAS Number: 81-27-6
• Complexity: 1550
• IUPAC Name: (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracene-2-carboxylic acid
• InChI: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
• InChI Key: IPQVTOJGNYVQEO-KGFNBKMBSA-N
• Exact Mass: 862.19564360
• Molecular Formula: C42H38O20
• Molecular Weight: 862.7
• SMILES: C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C([C@@H]2[C@@H]5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
• Topological: 348
• Monoisotopic Mass: 862.19564360
• Physical Description: Senna is a yellow-brown powder with a slight odor and taste.
• Melting Point: 392 °F approximately
• Solubility: less than 1 mg/mL at 66 °F
• Synonyms: 8013-11-4, Dosaflex, Gentlax, Sennalax, Senolax, Black Draught, CCRIS 7489, SENNA, Sennoside A, 81-27-6, Senokot, sennoside, 2F1O30GVXH, CHEBI:9112, (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid, DTXSID1023576, [9,9′-Bianthracene]-2,2′-dicarboxylic acid,5,5′-bis(b-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-, (R*,R*)-, C42H38O20, Sennae folium, (9R,9’R)-4,4′-Dihydroxy-10,10′-dioxo-5,5′-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9′,10,10′-tetrahydro-[9,9′-bianthracene]-2,2′-dicarboxylic acid, EINECS 201-339-9, UNII-2F1O30GVXH, NSC 112929, Glaxenna, Amyran, Exprep, Moivat, Senan, NSC112929, Tisasen A, NSC-112929, Senna (powdered), Sennoside A, G, NCGC00095095-01, 85085-71-8, MFCD00151527, Sennoside A (Standard), Sennosides A + B 99%, SCHEMBL440792, SENNOSIDE A [USP-RS], SENNOSIDE A [WHO-DD], DTXCID803576, MEGxp0_001902, CHEMBL2368547, NIOSH/VT6020000, ACon0_001464, BDBM92481, HY-N0365R, IPQVTOJGNYVQEO-KGFNBKMBSA-N, HMS3885E20, MSK40350, SENNOSIDES SENNOSIDE A [MI], Tox21_111420, LMPK13040016, AKOS015960468, AC-6075, CCG-270540, MS08136, CAS-81-27-6, SMP1_000271, NCGC00385183-01, 1ST40350, AS-75207, AS-80195, NS00009828, S4033, VT60200000, Q27108275, SENNOSIDE A (CONSTITUENT OF SENNA LEAF AND PODS) [DSC], (-)-(9R*,9’R*)-5,5′-bis(beta-D-glucopyranosyloxy)-4,4′-dihydroxy-10,10′-dioxo-9,9′,10,10′-tetrahydro-9,9′-bianthracene-2,2′-dicarboxylic acid, (9,9′-BIANTHRACENE)-2,2′-DICARBOXYLIC ACID, 5,5′-BIS(.BETA.-D-GLUCOPYRANOSYLOXY)-9,9′,10,10′-TETRAHYDRO-4,4′-DIHYDROXY-10,10′-DIOXO-, (9R,9’R)-, (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4 ,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hyd roxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4 ,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid, (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracene-2-carboxylic acid, (9R*,9’R*)-5,5′-bis(beta-D-glucopyranosyloxy)-4,4′-dihydroxy-10,10′-dioxo-9,9′,10,10′-tetrahydro-9,9′-bianthracene-2,2′-dicarboxylic acid, (9R,9’R)-4,4′-dihydroxy-10,10′-dioxo-5,5′-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})-9H,9’H,10H,10’H-[9,9′-bianthracene]-2,2′-dicarboxylic acid, (9R,9’R)-5,5′-bis(beta-D-glucopyranosyloxy)-4,4′-dihydroxy-10,10′-dioxo-9,9′,10,10′-tetrahydro-9,9′-bianthracene-2,2′-dicarboxylic acid, (9R,9’S)-4,4′-dihydroxy-10,10′-dioxo-5,5′-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})-9H,9’H,10H,10’H-[9,9′-bianthracene]-2,2′-dicarboxylic acid, (9R,9R)-5,5-BIS(.BETA.-D-GLUCOPYRANOSYLOXY)-9,9,10,10-TETRAHYDRO-4,4-DIHYDROXY-10,10-DIOXO(9,9-BIANTHRACENE)-2,2-DICARBOXYLIC ACID, (R*,R*)-5,5′-BIS(.BETA.-D-GLUCOPYRANOSYLOXY)-9,9′,10,10′-TETRAHYDRO-4,4′-DIHYDROXY-10,10′-DIOXO(9,9′-BIANTHRACENE)-2,2′-DICARBOXYLIC ACID, [9,9′ -Bianthracene] -2,2′ -dicarboxylic acid, 5,5′ -bis(.beta. -D-glucopyranosyloxy) -9,9′ ,10,10′ -tetrahydro-4,4′ – dihydroxy-10,10′ -dioxo-, (R*,R*) – (9CI)

Senna is primarily utilized as a stimulant laxative in over-the-counter and prescription medications for temporary relief of constipation. Its active metabolites, sennosides A and B, are activated by gut microbiota to promote peristalsis and fluid secretion in the colon. Researchers employ Senna in pharmacokinetic studies of anthraquinone glycosides and investigations of natural product metabolism. It also serves as a reference standard in HPLC-based quality control assays for herbal supplements.

Safety and Hazards

GHS Hazard Statements

• H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

Precautionary Statements

• P233, P260, P271, P284, P304+P340, P342+P316, P403, and P501

Hazard Classes and Categories

• Acute Tox. 4 (66.7%)
• Skin Sens. 1B (33.3%)
• Resp. Sens. 1B (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.