Description

Salcaprozate Sodium (CAS No. 203787-91-1) is a high-purity pharmaceutical excipient and absorption enhancer with the molecular formula C₁₅H₂₀NNaO₄. This compound, also known by its IUPAC name sodium;8-[(2-hydroxybenzoyl)amino]octanoate, is widely utilized in drug formulation research to improve the bioavailability of poorly absorbed active pharmaceutical ingredients (APIs). Our Salcaprozate Sodium is synthesized under strict GMP conditions and undergoes rigorous QC testing including HPLC, NMR, and mass spectrometry to ensure ≥98% purity. Available in milligram to kilogram quantities, this white to off-white crystalline powder is packaged under inert atmosphere to ensure stability. Ideal for research in oral drug delivery systems, this product is supplied with comprehensive analytical documentation including CoA and MSDS.

Properties

• CAS Number: 203787-91-1
• Complexity: 312
• IUPAC Name: sodium;8-[(2-hydroxybenzoyl)amino]octanoate
• InChI: InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1
• InChI Key: UOENJXXSKABLJL-UHFFFAOYSA-M
• Exact Mass: 301.12900240
• Molecular Formula: C15H20NNaO4
• Molecular Weight: 301.31
• SMILES: C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+]
• Topological: 89.5
• Monoisotopic Mass: 301.12900240
• Synonyms: Salcaprozate sodium, 203787-91-1, sodium 8-[(2-hydroxybenzoyl)amino]octanoate, Salcaprozate sodium [USAN], Sodium salcaprozate, UNII-1YTW0422YU, Salcaprozic acid, sodium salt, 1YTW0422YU, Salcaprozate sodium (USAN), E 414, E-414, Sodium 8-((2-hydroxybenzoyl)amino)octanoate, DTXSID50174306, SNAC sodium, DTXCID3096797, 807-387-2, sodium 8-(2-hydroxybenzamido)octanoate, SNAC, sodium;8-[(2-hydroxybenzoyl)amino]octanoate, E414, Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt, Salcaprozate (sodium), MFCD00952954, sodium,8-[(2-hydroxybenzoyl)amino]octanoate, Octanoic acid, 8-((2-hydroxybenzoyl)amino)-, monosodium salt, C15H20NNaO4, Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt, Salcaprozic acid sodium salt, SCHEMBL825599, CHEMBL2107027, Salcaprozate (sodium) (Standard), UOENJXXSKABLJL-UHFFFAOYSA-M, EX-A3434, Sodium 8-(salicyloylamino)octanoate, sodium8-(2-hydroxybenzamido)octanoate, AKOS027252576, HY-114299R, AC-31357, AS-65676, DA-67382, FS168567, P414, SY111977, HY-114299, CS-0081977, D05787, I10998, Q27253228, SODIUM 8-[(2-HYDROXYPHENYL)FORMAMIDO]OCTANOATE

Application

Salcaprozate Sodium is primarily employed as a non-toxic absorption enhancer in oral pharmaceutical formulations, particularly for peptides and poorly permeable small molecules. It functions by transiently modulating intestinal epithelial tight junctions to facilitate paracellular transport. Researchers utilize this compound in preclinical studies to improve the oral bioavailability of challenging APIs while maintaining epithelial integrity. Its applications extend to development of solid dispersions and lipid-based delivery systems for enhanced drug solubility.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P319, P330, P337+P317, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.