Description
(S)-(Tetrahydrofuran-3-yl)hydrazine hydrochloride (CAS: 1364632-45-0) is a high-purity chiral hydrazine derivative with the molecular formula C4H11ClN2O. This compound features a tetrahydrofuran ring with a hydrazine moiety at the (S)-configured 3-position, making it a valuable intermediate in asymmetric synthesis and pharmaceutical research. The hydrochloride salt form enhances stability and solubility for precise laboratory applications. Ideal for researchers in medicinal chemistry, it serves as a building block for the development of bioactive molecules, heterocyclic compounds, and ligands for catalysis. Available in rigorously controlled batches with ≥95% purity (HPLC), this reagent is supplied with comprehensive analytical data (NMR, MS) to ensure reproducibility in sensitive experiments.
Properties
- CAS Number: 1364632-45-0
- Complexity: 57.7
- IUPAC Name: [(3S)-tetrahydrofuran-3-yl]hydrazine;hydrochloride
- InChI: InChI=1S/C4H10N2O.ClH/c5-6-4-1-2-7-3-4;/h4,6H,1-3,5H2;1H/t4-;/m0./s1
- InChI Key: KUFARIZPHSIGFQ-WCCKRBBISA-N
- Exact Mass: 138.0559907
- Molecular Formula: C4H11ClN2O
- Molecular Weight: 138.59
- SMILES: C1COC[C@H]1NN.Cl
- Topological: 47.3
- Monoisotopic Mass: 138.0559907
- Synonyms: 1364632-45-0, (S)-(Tetrahydrofuran-3-yl)hydrazine hydrochloride, (3S)-(Tetrahydro-furan-3-yl)-hydrazine hydrochloride, [(3S)-oxolan-3-yl]hydrazine;hydrochloride, MFCD28098096, SCHEMBL14990279, [(3S)-oxolan-3-yl]hydrazine hydrochloride, CS-0340066, F15303, (S)-(TETRAHYDROFURAN-3-YL)HYDRAZINE HCL, (S)-(Tetrahydrofuran-3-yl)hydrazinehydrochloride
This compound is widely used as a chiral precursor in the synthesis of pharmaceuticals, particularly for introducing hydrazine functionality in stereoselective reactions. It is employed in the preparation of heterocyclic scaffolds for drug discovery, such as pyrazoles and triazoles. Researchers also utilize it in asymmetric catalysis and as a ligand modifier in transition-metal complexes. Its stability and reactivity make it suitable for controlled hydrazone and hydrazide formations in peptide-mimetic studies.
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