Description

Description

(S)-2-Amino-3-(4-fluorophenyl)-2-methylpropanoic acid (CAS No. 130855-57-1) is a high-purity fluorinated amino acid derivative with the molecular formula C₁₀H₁₂FNO₂. This chiral compound, also known as alpha-methyl-L-4-Fluorophenylalanine, features a stereospecific (S)-configuration and a methyl substitution at the alpha-position, making it a valuable building block for peptidomimetics and pharmaceutical research. The 4-fluorophenyl moiety enhances metabolic stability and bioavailability in drug design applications. Supplied as a white to off-white crystalline powder, this reagent is characterized by HPLC purity ??95% and is rigorously tested for heavy metals, residual solvents, and chiral purity. Ideal for medicinal chemistry, it is packaged under inert gas in amber glass vials to ensure long-term stability. Store at 2-8??C in a dry environment.

Application

This fluorinated non-natural amino acid is widely used as a key intermediate in the synthesis of protease inhibitors and kinase-targeted therapeutics. Its structural rigidity and enhanced lipophilicity make it valuable for improving peptide stability and membrane permeability in drug candidates. Researchers employ it in structure-activity relationship (SAR) studies for CNS drugs due to its ability to cross the blood-brain barrier. The compound is also utilized in PET tracer development, leveraging the fluorine-19 atom for potential ¹⁸F radiolabeling applications.

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