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Atomfair (S)-2-Amino-2-methyl-3-(4-(trifluoromethoxy)phenyl)propanoic acid C11H12F3NO3

Description (S)-2-Amino-2-methyl-3-(4-(trifluoromethoxy)phenyl)propanoic acid (CAS No. 1269926-90-0) is a high-purity, non-natural amino acid derivative designed for advanced research applications. With the molecular formula C11H12F3NO3, this compound features a chiral center at the alpha-carbon and a trifluoromethoxy-substituted phenyl group, offering unique steric and electronic properties. Its IUPAC name, (2S)-2-amino-2-methyl-3-[4-(trifluoromethoxy)phenyl]propanoic acid , reflects its precise stereochemistry. This product is ideal for peptide modification, medicinal chemistry, and biochemical studies, where its methylated backbone and fluorine-rich aromatic moiety can enhance metabolic stability and binding affinity. Supplied as a white to off-white crystalline powder with ??95% purity (HPLC), it is rigorously characterized by1H/13C NMR, LC-MS, and…

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Description

Description

(S)-2-Amino-2-methyl-3-(4-(trifluoromethoxy)phenyl)propanoic acid (CAS No. 1269926-90-0) is a high-purity, non-natural amino acid derivative designed for advanced research applications. With the molecular formula C11H12F3NO3, this compound features a chiral center at the alpha-carbon and a trifluoromethoxy-substituted phenyl group, offering unique steric and electronic properties. Its IUPAC name, (2S)-2-amino-2-methyl-3-[4-(trifluoromethoxy)phenyl]propanoic acid, reflects its precise stereochemistry. This product is ideal for peptide modification, medicinal chemistry, and biochemical studies, where its methylated backbone and fluorine-rich aromatic moiety can enhance metabolic stability and binding affinity. Supplied as a white to off-white crystalline powder with ??95% purity (HPLC), it is rigorously characterized by 1H/13C NMR, LC-MS, and chiral HPLC to ensure batch consistency. Store desiccated at -20??C for long-term stability.

  • CAS No: 1269926-90-0
  • Molecular Formula: C11H12F3NO3
  • Molecular Weight: 263.21
  • Exact Mass: 263.07692773
  • Monoisotopic Mass: 263.07692773
  • IUPAC Name: (2S)-2-amino-2-methyl-3-[4-(trifluoromethoxy)phenyl]propanoic acid
  • SMILES: C[C@](CC1=CC=C(C=C1)OC(F)(F)F)(C(=O)O)N
  • Synonyms: 1269926-90-0, (S)-2-Amino-2-methyl-3-(4-(trifluoromethoxy)phenyl)propanoic acid, L-Tyrosine, alpha-methyl-O-(trifluoromethyl)-, (2S)-2-AMINO-2-METHYL-3-[4-(TRIFLUOROMETHOXY)PHENYL]PROPANOIC ACID, (S)-alpha-Methyl 4-Trifluoromethoxyphenylalaine;alpha-Me-Phe(4-OCF3)-OH

Application

This chiral amino acid derivative serves as a critical building block in peptidomimetic drug discovery, particularly for targeting GPCRs and enzymes where fluorine substitution modulates bioavailability. The trifluoromethoxy group enhances lipophilicity for improved blood-brain barrier penetration in CNS drug candidates. Researchers utilize it to introduce conformational constraints in peptide backbones or as a probe for 19F NMR studies. Its structural features make it valuable for developing protease-resistant analogs in therapeutic peptide design.

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