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Atomfair (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid FMoc-alpha-Me-Asp(OtBu)-OH C24H27NO6

Description (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid (CAS: 1072845-47-6) is a high-purity, synthetic amino acid derivative designed for advanced peptide synthesis and biochemical research. With the molecular formula C24H27NO6, this Fmoc-protected, tert-butyl ester-modified compound offers exceptional stability and reactivity for solid-phase peptide synthesis (SPPS). The stereospecific (S)-configuration and alpha-methyl substitution provide unique conformational constraints, making it invaluable for studying peptide structure-activity relationships. Packaged under inert conditions to ensure maximum shelf life, this product is ideal for researchers requiring precise control over peptide backbone modifications. Each batch is rigorously analyzed by HPLC, NMR, and MS to guarantee >98% chemical purity.

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Description

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid (CAS: 1072845-47-6) is a high-purity, synthetic amino acid derivative designed for advanced peptide synthesis and biochemical research. With the molecular formula C24H27NO6, this Fmoc-protected, tert-butyl ester-modified compound offers exceptional stability and reactivity for solid-phase peptide synthesis (SPPS). The stereospecific (S)-configuration and alpha-methyl substitution provide unique conformational constraints, making it invaluable for studying peptide structure-activity relationships. Packaged under inert conditions to ensure maximum shelf life, this product is ideal for researchers requiring precise control over peptide backbone modifications. Each batch is rigorously analyzed by HPLC, NMR, and MS to guarantee >98% chemical purity.

  • CAS No: 1072845-47-6
  • Molecular Formula: C24H27NO6
  • Molecular Weight: 425.5
  • Exact Mass: 425.18383758
  • Monoisotopic Mass: 425.18383758
  • IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
  • SMILES: C[C@](CC(=O)OC(C)(C)C)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
  • Synonyms: 1072845-47-6, (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid, FMoc-alpha-Me-Asp(OtBu)-OH, (S)-Fmoc-2-amino-2-methyl-succinic acid-4-tert-butyl ester, Fmoc-|A-Me-Asp(OtBu)-OH

Application

This specialized amino acid derivative is primarily used in peptide synthesis to introduce steric hindrance and modulate secondary structure. It serves as a critical building block for conformationally constrained peptides in drug discovery and protein engineering. The tert-butyl ester protection allows orthogonal deprotection strategies in multi-step syntheses. Researchers employ it to investigate protease resistance and peptide stability in biological systems.

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