Description

(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine hydrochloride (CAS: 1391540-47-8) is a high-purity chiral amine hydrochloride derivative, widely utilized in pharmaceutical research and organic synthesis. With the molecular formula C₉H₁₁ClF₃NO, this compound features a trifluoromethoxy-substituted phenyl ring and an (S)-configured ethylamine moiety, making it a valuable intermediate for drug discovery and asymmetric synthesis. The hydrochloride salt enhances stability and solubility, ensuring reliable performance in laboratory applications. This product is rigorously tested to meet stringent quality standards, including HPLC, NMR, and mass spectrometry verification, guaranteeing ≥98% purity for optimal research outcomes. Suitable for use in medicinal chemistry, neuroscience studies, and as a building block for bioactive molecules, it is supplied in secure packaging to maintain integrity under controlled storage conditions.

Properties

• CAS Number: 1391540-47-8
• Complexity: 175
• IUPAC Name: (1S)-1-[4-(trifluoromethoxy)phenyl]ethanamine;hydrochloride
• InChI: InChI=1S/C9H10F3NO.ClH/c1-6(13)7-2-4-8(5-3-7)14-9(10,11)12;/h2-6H,13H2,1H3;1H/t6-;/m0./s1
• InChI Key: CRAQSXJYHZMDFP-RGMNGODLSA-N
• Exact Mass: 241.0481262
• Molecular Formula: C9H11ClF3NO
• Molecular Weight: 241.64
• SMILES: C[C@@H](C1=CC=C(C=C1)OC(F)(F)F)N.Cl
• Topological: 35.3
• Monoisotopic Mass: 241.0481262
• Synonyms: 1391540-47-8, (S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine hydrochloride, (S)-1-[4-(Trifluoromethoxy)phenyl]ethanamine Hydrochloride, 813-557-7, (1S)-1-[4-(trifluoromethoxy)phenyl]ethan-1-amine hydrochloride, Benzenemethanamine, alpha-methyl-4-(trifluoromethoxy)-, hydrochloride (1:1), (alphaS)-, (1S)-1-[4-(trifluoromethoxy)phenyl]ethanamine;hydrochloride, MFCD12757222, (1S)-1-[4-(trifluoromethoxy)phenyl]ethanamine hydrochloride, (S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine HCl, SCHEMBL14120857, CS-B0922, RFC54047, AKOS024462801, CPD109174-A4?, GS-7303, DS-019111, EN300-177356, Y10713, (S)-1-(4-(Trifluoromethoxy)phenyl)ethanaminehydrochloride, Benzenemethanamine, |A-methyl-4-(trifluoromethoxy)-, hydrochloride (1:1), (|AS)-

(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine hydrochloride is primarily employed as a key chiral intermediate in the synthesis of pharmaceuticals targeting neurological and psychiatric disorders. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, making it valuable in CNS drug development. Researchers also utilize it in asymmetric catalysis and as a ligand in metal-organic frameworks. The compound’s enantiomeric purity is critical for studies involving receptor binding assays and enzyme inhibition. It is commonly referenced in patent literature for novel therapeutic agents.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.