Description

Rimegepant Sulfate (CAS No. 1374024-48-2) is a high-purity pharmaceutical compound with the molecular formula C₅₆H₆₄F₄N₁₂O₁₃S, primarily used as a calcitonin gene-related peptide (CGRP) receptor antagonist. This sulfate salt form of Rimegepant is a sesquihydrate, ensuring enhanced stability and solubility for therapeutic applications. It is marketed under the brand name Nurtec ODT (orally disintegrating tablet) for the acute treatment of migraine in adults. Our product is rigorously tested for purity, potency, and consistency, meeting USP/EP standards for research and clinical use. Each batch is supplied with comprehensive analytical documentation, including HPLC, NMR, and mass spectrometry data.

This small molecule inhibitor selectively targets the CGRP pathway, offering rapid relief from migraine symptoms without vasoconstrictive effects. Available in milligram quantities for laboratory use or bulk quantities for formulation development, Rimegepant Sulfate is ideal for pharmacokinetic studies, drug delivery research, and preclinical investigations.

Properties

• CAS Number: 1374024-48-2
• Complexity: 973
• IUPAC Name: [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;sulfuric acid;trihydrate
• InChI: InChI=1S/2C28H28F2N6O3.H2O4S.3H2O/c2*29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37;1-5(2,3)4;;;/h2*1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37);(H2,1,2,3,4);3*1H2/t2*18-,22+,24-;;;;/m00…./s1
• InChI Key: SOGUOEZRYKUOHR-CQZKMDJHSA-N
• Exact Mass: 1220.43726396
• Molecular Formula: C56H64F4N12O13S
• Molecular Weight: 1221.2
• SMILES: C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.O.O.O.OS(=O)(=O)O
• Topological: 313
• Monoisotopic Mass: 1220.43726396
• Synonyms: Rimegepant sulfate, Nurtec ODT, 1374024-48-2, UNII-1383NM3Q0H, 1383NM3Q0H, DTXSID60160174, RIMEGEPANT HEMISULFATE SESQUIHYDRATE, 1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo(4,5-b)pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta(b)pyridin-9-yl ester, sulfate, hydrate (2:1:3), Di((5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta(b)pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxylate), monosulfate, trihydrate, Di{(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate}, monosulfate, trihydrate, DTXCID9082665, Rimegepant sulfate [USAN], Rimegepant sulfate (USAN), Nurtec odt (TN), Vydura (TN), rimegepant sulfate dihydrate, CHEMBL2364629, RIMEGEPANT SULFATE HYDRATE, Rimegepant sulfate hydrate (JAN), RIMEGEPANT SULFATE [WHO-DD], RIMEGEPANT SULFATE [ORANGE BOOK], D10663, H37711, RIMEGEPANT HEMISULFATE SESQUIHYDRATE [MI], Q27251488

Rimegepant Sulfate is a potent CGRP receptor antagonist approved for the acute treatment of migraine with or without aura. It provides fast-acting relief by blocking the CGRP-mediated vasodilation and neurogenic inflammation associated with migraines. Researchers utilize this compound to study its pharmacokinetics, receptor binding affinity, and therapeutic efficacy in neurological disorders. Its orally disintegrating tablet formulation (Nurtec ODT) is optimized for bioavailability and patient compliance. Additionally, Rimegepant Sulfate serves as a reference standard in analytical method development and quality control testing.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H361 (50%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
• H361d (50%): Suspected of damaging the unborn child [Warning Reproductive toxicity]
• H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P260, P264, P270, P280, P301+P317, P318, P319, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Repr. 2 (50%)
• Repr. 2 (50%)
• STOT RE 2 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.