Description
rac-tert-butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate (CAS: 1932056-72-8) is a high-purity chiral piperidine derivative designed for advanced pharmaceutical and chemical research applications. This compound features a tert-butoxycarbonyl (Boc) protecting group and a fluorine substitution at the 5-position, making it a versatile intermediate in medicinal chemistry and drug discovery. With the molecular formula C10H19FN2O2, it offers excellent stability and reactivity for stereoselective synthesis. Ideal for researchers developing bioactive molecules, this product is rigorously tested for purity (≥95% by HPLC) and is supplied in sealed containers under inert gas to ensure long-term integrity. Store at 2-8°C in a dry environment to maintain optimal performance.
Properties
- CAS Number: 1932056-72-8
- Complexity: 240
- IUPAC Name: tert-butyl (3S,5S)-3-amino-5-fluoro-piperidine-1-carboxylate
- InChI: InChI=1S/C10H19FN2O2/c1-10(2,3)15-9(14)13-5-7(11)4-8(12)6-13/h7-8H,4-6,12H2,1-3H3/t7-,8-/m0/s1
- InChI Key: QHVIBSNJHHGNCZ-YUMQZZPRSA-N
- Exact Mass: 218.14305602
- Molecular Formula: C10H19FN2O2
- Molecular Weight: 218.27
- SMILES: CC(C)(C)OC(=O)N1C[C@H](C[C@@H](C1)F)N
- Topological: 55.6
- Monoisotopic Mass: 218.14305602
- Synonyms: tert-butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate, 1932056-72-8, 1638772-27-6, RAC-TERT-BUTYL (3R,5R)-3-AMINO-5-FLUOROPIPERIDINE-1-CARBOXYLATE, 816-139-2, 860-638-8, (3S,5S)-tert-Butyl 3-amino-5-fluoropiperidine-1-carboxylate, rac-tert-butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate, trans, MFCD30181025, (3S,5S)-1-Boc-3-amino-5-fluoropiperidine, CHEMBL4589098, SCHEMBL20497892, AKOS030627761, DB-144713, CS-0055771, EN300-300141, P15617, EN300-6490282, Z2311227707, t-Butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate, (3S,5S)-tert-Butyl3-amino-5-fluoropiperidine-1-carboxylate
This compound serves as a key chiral building block in the synthesis of fluorinated pharmaceuticals, particularly for CNS-targeting drugs and enzyme inhibitors. Its Boc-protected amino group enables selective deprotection for further functionalization, while the fluorine atom enhances metabolic stability in drug candidates. Researchers utilize it in asymmetric synthesis, peptide mimetics, and structure-activity relationship (SAR) studies. The racemic mixture allows investigation of both enantiomers’ biological activity during early-stage drug development.
Safety and Hazards
GHS Hazard Statements
- H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
- Acute Tox. 4 (100%)
- Skin Irrit. 2 (100%)
- Eye Irrit. 2A (100%)
- STOT SE 3 (100%)
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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.


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