Description

(R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate (CAS: 167216-17-3) is a high-purity chiral building block widely used in pharmaceutical and biochemical research. This compound, with the molecular formula C₉H₁₉NO₃, features a tert-butoxycarbonyl (Boc) protecting group, making it ideal for peptide synthesis and medicinal chemistry applications. Its (R)-enantiomeric form ensures stereochemical precision in asymmetric synthesis. The hydroxyl and carbamate functional groups provide versatile reactivity for further derivatization. Supplied as a white to off-white crystalline solid, this product is rigorously tested for purity (>98% by HPLC) and stability, ensuring reliable performance in sensitive reactions. Suitable for use in organic synthesis, catalyst development, and drug discovery.

Properties

• CAS Number: 167216-17-3
• Complexity: 163
• IUPAC Name: tert-butyl N-[(1R)-3-hydroxy-1-methyl-propyl]carbamate
• InChI: InChI=1S/C9H19NO3/c1-7(5-6-11)10-8(12)13-9(2,3)4/h7,11H,5-6H2,1-4H3,(H,10,12)/t7-/m1/s1
• InChI Key: JSZOAOLSEKSNTD-SSDOTTSWSA-N
• Exact Mass: 189.13649347
• Molecular Formula: C9H19NO3
• Molecular Weight: 189.25
• SMILES: C[C@H](CCO)NC(=O)OC(C)(C)C
• Topological: 58.6
• Monoisotopic Mass: 189.13649347
• Synonyms: 167216-17-3, (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate, Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI), TERT-BUTYL N-[(2R)-4-HYDROXYBUTAN-2-YL]CARBAMATE, (R)-N-BOC-3-AMINOBUTAN-1-OL, N-Boc-(R)-3-aminobutan-1-ol, MFCD18831346, SCHEMBL2389101, JSZOAOLSEKSNTD-SSDOTTSWSA-N, AKOS027252397, DS-10250, CS-0142509, (R)-tert-Butyl(4-hydroxybutan-2-yl)carbamate, EN300-2014338, tert-Butyl (R)-(4-hydroxybutan-2-yl)carbamate, ((R)-3-hydroxy-1-methyl-propyl)-carbamic acid tert-butyl ester, CARBAMIC ACID, [(1R)-3-HYDROXY-1-METHYLPROPYL]-, 1,1-DIMETHYLETHYL, N-beta-t-Butoxycarbonyl-L-beta-homoalaniol;(S)-3-[(t-Butoxycarbonyl)amino]-1-butanol

(R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate is primarily employed as a chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) and peptidomimetics. It serves as a key precursor for the preparation of β-amino alcohols and other bioactive molecules. Researchers utilize this compound in asymmetric catalysis and enantioselective transformations. Its Boc-protected amine group facilitates controlled deprotection under mild acidic conditions, enabling sequential functionalization.

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