Atomfair

Awaiting product image

Atomfair (R)-N-Fmoc-alpha-methylasparagine FMoc-alpha-Me-D-Asn-OH C20H20N2O5

Description (R)-N-Fmoc-alpha-methylasparagine (CAS: 1403590-50-0) is a high-purity, chiral amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. With the molecular formula C20H20N2O5, this compound features an Fmoc-protected alpha-methylated asparagine side chain, offering enhanced steric control and stability in solid-phase peptide synthesis (SPPS). Its IUPAC name, (2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-4-oxobutanoic acid , reflects its precise stereochemistry, critical for maintaining peptide conformation and biological activity. Ideal for researchers developing constrained peptides or peptidomimetics, this product is rigorously tested via HPLC and NMR to ensure ??95% purity, meeting stringent standards for drug discovery and biochemical studies. Supplied as a white to off-white powder, it…

Category:
Brands:

Description

Description

(R)-N-Fmoc-alpha-methylasparagine (CAS: 1403590-50-0) is a high-purity, chiral amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. With the molecular formula C20H20N2O5, this compound features an Fmoc-protected alpha-methylated asparagine side chain, offering enhanced steric control and stability in solid-phase peptide synthesis (SPPS). Its IUPAC name, (2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-4-oxobutanoic acid, reflects its precise stereochemistry, critical for maintaining peptide conformation and biological activity. Ideal for researchers developing constrained peptides or peptidomimetics, this product is rigorously tested via HPLC and NMR to ensure ??95% purity, meeting stringent standards for drug discovery and biochemical studies. Supplied as a white to off-white powder, it is stored under inert conditions to preserve reactivity.

  • CAS No: 1403590-50-0
  • Molecular Formula: C20H20N2O5
  • Molecular Weight: 368.4
  • Exact Mass: 368.13722174
  • Monoisotopic Mass: 368.13722174
  • IUPAC Name: (2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-4-oxobutanoic acid
  • SMILES: C[C@@](CC(=O)N)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
  • Synonyms: 1403590-50-0, (R)-N-Fmoc-alpha-methylasparagine, FMoc-alpha-Me-D-Asn-OH, D-Asparagine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-, (2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-4-oxobutanoic acid

Application

(R)-N-Fmoc-alpha-methylasparagine is widely used in peptide synthesis to introduce steric constraints and improve metabolic stability in therapeutic peptides. Its alpha-methylation prevents racemization during coupling steps, making it valuable for synthesizing enantiopure peptidomimetics. Researchers leverage this derivative in drug discovery for conditions like cancer and autoimmune diseases, where modified peptides enhance target binding. It is also employed in structural biology to study peptide-protein interactions with minimized conformational flexibility.

If you are interested or have any questions, please contact us at support@atomfair.com