Description

(R)-2-(4-chlorophenyl)piperazine (CAS No. 769944-51-6) is a high-purity chiral piperazine derivative with the molecular formula C₁₀H₁₃ClN₂. This compound features a stereospecific (R)-configuration at the 2-position of the piperazine ring, coupled with a 4-chlorophenyl substituent, making it a valuable intermediate in asymmetric synthesis and pharmaceutical research. Its IUPAC name, (2R)-2-(4-chlorophenyl)piperazine, reflects its precise structural configuration. Available as a white to off-white crystalline powder, it is characterized by excellent solubility in organic solvents such as methanol, ethanol, and DMSO, while exhibiting limited solubility in water. Rigorous quality control ensures ≥95% purity (HPLC), with trace impurities meticulously documented for research reproducibility. Suitable for use in medicinal chemistry, neuropharmacology, and ligand design, this compound is packaged under inert gas to ensure stability and shipped with comprehensive analytical data (MSDS, NMR, HPLC).

Properties

• CAS Number: 769944-51-6
• Complexity: 155
• IUPAC Name: (2R)-2-(4-chlorophenyl)piperazine
• InChI: InChI=1S/C10H13ClN2/c11-9-3-1-8(2-4-9)10-7-12-5-6-13-10/h1-4,10,12-13H,5-7H2/t10-/m0/s1
• InChI Key: OTOVNNDSINVUBR-JTQLQIEISA-N
• Exact Mass: 196.0767261
• Molecular Formula: C10H13ClN2
• Molecular Weight: 196.67
• SMILES: C1CN[C@@H](CN1)C2=CC=C(C=C2)Cl
• Topological: 24.1
• Monoisotopic Mass: 196.0767261
• Synonyms: (R)-2-(4-chlorophenyl)piperazine, 769944-51-6, (2R)-2-(4-chlorophenyl)piperazine, rel-(2R)-2-(4-chlorophenyl)piperazine, SCHEMBL1673686, CS-0268162, P10458, EN300-2010080

Application

(R)-2-(4-chlorophenyl)piperazine serves as a key chiral building block in the synthesis of bioactive molecules, particularly serotonin and dopamine receptor ligands. Its structural motif is exploited in the development of CNS-targeting pharmaceuticals, including potential antipsychotics and antidepressants. Researchers utilize this compound to study stereospecific binding interactions in neurotransmitter systems. It also finds application in asymmetric catalysis and as a scaffold for library design in high-throughput screening.

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.