Description

(R)-1-N-Boc-3-hydroxypyrrolidine (CAS No. 109431-87-0) is a high-purity chiral building block widely used in pharmaceutical and organic synthesis. This compound, with the molecular formula C₉H₁₇NO₃, features a pyrrolidine ring with a Boc-protected nitrogen and a hydroxyl group at the 3-position in the (R)-configuration. It serves as a versatile intermediate for the preparation of bioactive molecules, including protease inhibitors, chiral ligands, and other enantiomerically pure compounds. With exceptional chemical stability and compatibility with various reaction conditions, it is an essential reagent for researchers developing novel therapeutics and fine chemicals. Supplied in rigorously tested batches, this product ensures consistency and reliability for critical synthetic applications.

Properties

• CAS Number: 109431-87-0
• Complexity: 198
• IUPAC Name: tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate
• InChI: InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m1/s1
• InChI Key: APCBTRDHCDOPNY-SSDOTTSWSA-N
• Exact Mass: 187.12084340
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.24
• SMILES: CC(C)(C)OC(=O)N1CC[C@H](C1)O
• Topological: 49.8
• Monoisotopic Mass: 187.12084340
• Synonyms: 109431-87-0, (R)-1-N-Boc-3-hydroxypyrrolidine, (R)-(-)-N-Boc-3-pyrrolidinol, (R)-1-Boc-3-hydroxypyrrolidine, (r)-n-(tert-butoxycarbonyl)-3-hydroxypyrrolidine, tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, (R)-1-N-Boc-3-hydroxy-pyrrolidine, (r)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate, (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester, MFCD01317838, (R)-N-tert-Butoxycarbonyl-(-)-3-pyrrolidinol, N-BOC-(R)-3-HYDROXYPYRROLIDINE, (r)-n-boc-3-pyrrolidinol, N-Boc-3-pyrrolidinol, (r)-(-)-boc-3-pyrrolidinol, (R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine, r-bochp, (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol, 1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R)-, BOC-(R)-3-pyrrolidinol, N-tert-butoxycarbonyl-(R)–(-)-3-pyrrolidinol, (R)-1-Boc-3-pyrrolidinol, SCHEMBL14494, (r)-n-boc-3-hydroxy-pyrrolidine, DTXSID40424908, R)-(-)-N-Boc-3-pyrrolidinol, TERT-BUTYL (R)-3-HYDROXYPYRROLIDINE-1-CARBOXYLATE, (3R)-3-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester, (R)-3-hydroxy-N-Boc-pyrrolidine, (R)-3-Hydroxypyrrolidine-1-carboxylic acid tert-butyl ester, N-Boc-(R)-(-)-3-pyrrolidinol, (3R)-N-BOC-3-Hydroxypyrrolidine, (R)-(+)-1-Boc-3-pyrrolidinol, (3R)-1-BOC-3-hydroxypyrrolidine, BCP15468, AC-139, AKOS005145919, AKOS015838269, (3r)-(-)-n-boc-3-hydroxypyrrolidine, CS-W001294, HY-W001294, PS-3869, (3R)-(-) -N-BOC-3-hydroxypyrrolidine, (R)-(-)-N-Boc-3-pyrrolidinol, 98%, BP-13370, (3R)-N-tert-butoxycarbonylpyrrolidin-3-ol, (3R)-1-tert-butoxycarbonyl-3-pyrrolidinol, DB-005019, DB-030997, (3R)-N-tert-butyloxycarbonylpyrrolidin-3-ol, (R)-1-t-butoxycarbonyl-3-hydroxypyrrolidine, 1-t-butoxycarbonyl-3-(R)-hydroxypyrrolidine, B3054, N-(Tert-butoxycarbonyl)-(R)-3-pyrrolidinol, (3R)-1-t-butoxycarbonyl-3-hydroxypyrrolidine, (R)-3-hydroxy-1-tert-butoxycarbonylpyrrolidine, B52010, EN300-116612, N-tert-Butoxycarbonyl-(R)-(-)-3-pyrrolidinol, N-tert-butoxycarbonyl-(R)-3-hydroxypyrrolidine, t-butyl(3R)-3-hydroxypyrrolidine-1-carboxylate, (3R)-1-(t-butoxycarbonyl)-3-hydroxypyrrolidine, (3R)-1-tert-butoxycarbonyl-3-hydroxypyrrolidine, (3R)-N-(t-Butoxycarbonyl)-3-hydroxypyrrolidine, (3R)-N-tert-butoxycarbonyl-3-hydroxypyrrolidine, t-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, tert-butyl(R)-3-hydroxypyrrolidine-1-carboxylate, (R)-tert-butyl 3-hydroxypyrrolidin-1-carboxylate, (R)-tert-butyl-3-hydroxypyrrolidin-1-carboxylate, A800671, tert-butyl 3-(R)-hydroxypyrrolidine-1-carboxylate, tert-butyl(3R)-3-hydroxypyrrolidine-1-carboxylate, tert-butyl(R)-3-hydroxy-pyrrolidine-1-carboxylate, (3R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine, tert-butyl (3R)-3-oxidanylpyrrolidine-1-carboxylate, (R)-3-hydroxypyrrolidine-1-carboxylic acid t-butyl ester, 1,1-Dimethylethyl (3R)-3-hydroxy-1-pyrrolidinecarboxylate, 1,1-Dimethylethyl (3R)-3-hydroxypyrrolidine-1-carboxylate, 3-(R)-Hydroxy-pyrrolidine-1-carboxylicacidtert-butylester, (3R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester, (3R)-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester, (R)-3-Hydroxypyrrolidine-1 -carboxylic acid tert-butyl ester, (R)-(-)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

(R)-1-N-Boc-3-hydroxypyrrolidine is extensively used as a chiral synthon in asymmetric synthesis, particularly for constructing pharmacologically active pyrrolidine derivatives. It is a key intermediate in the synthesis of HIV protease inhibitors and other antiviral agents. The Boc-protected hydroxyl group allows for selective functionalization, making it valuable for peptide mimetics and catalyst design. Researchers also employ it in the development of enantioselective catalysts and ligands for transition-metal complexes.

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