Description

Pyridoxamine Dihydrochloride (CAS No. 524-36-7) is a high-purity biochemical compound widely utilized in research and pharmaceutical applications. With the molecular formula C₈H₁₄Cl₂N₂O₂, this hydrochloride salt of pyridoxamine serves as a critical intermediate in metabolic studies, particularly those involving vitamin B₆ pathways. Its crystalline form ensures excellent solubility in aqueous solutions, making it ideal for in vitro and in vivo studies. This reagent-grade product is rigorously tested for purity (≥99% by TLC) and is available in multiple packaging options to suit laboratory needs, including cell culture and analytical standards. Store in a cool, dry environment to maintain stability.

Properties

• CAS Number: 524-36-7
• Complexity: 143
• IUPAC Name: 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-pyridin-3-ol;dihydrochloride
• InChI: InChI=1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H
• InChI Key: HNWCOANXZNKMLR-UHFFFAOYSA-N
• Exact Mass: 240.0432331
• Molecular Formula: C8H14Cl2N2O2
• Molecular Weight: 241.11
• SMILES: CC1=NC=C(C(=C1O)CN)CO.Cl.Cl
• Topological: 79.4
• Monoisotopic Mass: 240.0432331
• Physical Description: Solid; White to off-white solid;
• Vapor Pressure: 0.00000144 [mmHg]
• Synonyms: PYRIDOXAMINE DIHYDROCHLORIDE, 524-36-7, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride, Pyridoxamine 2HCl, Pyridorin, Pyridoxamine dichlorohydrate, Pyridoxylamine dihydrochloride, 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride, UNII-YQ8NCR7V0O, YQ8NCR7V0O, EINECS 208-357-6, NSC 21278, DTXSID6045088, 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridene dihydrochloride, DTXCID4025088, CHEBI:131532, 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride, PYRIDOXAMINE DIHYDROCHLORIDE [MI], PYRIDOXAMINE HYDROCHLORIDE [MART.], PYRIDOXAMINE DIHYDROCHLORIDE [WHO-DD], 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride, NSC-21278, 4-aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride, 4-(azaniumylmethyl)-3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-1-ium dichloride, PYRIDOXAMINE HYDROCHLORIDE (MART.), 2Methyl3hydroxy4aminomethyl5hydroxymethylpyridene dihydrochloride, 4(Aminomethyl)5hydroxy6methyl3pyridinemethanol dihydrochloride, 3Pyridinemethanol, 4(aminomethyl)5hydroxy6methyl, dihydrochloride, 4(Aminomethyl)5hydroxy6methyl3pyridinemethanol hydrochloride (1:2), 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride (9CI), 208-357-6, Pyridoxylamine (dihydrochloride), Pyridoxamine DiHCl, MFCD00012808, 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-,dihydrochloride, 524-36-7 (HCl), K-163, Pyridoxamine-[D3] dihydrochloride (Vitamin B6-[D3]), 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol;dihydrochloride, CAS-524-36-7, pyridoxaminedihydrochloride, EN300-6481455, SCHEMBL48103, HY-B1745AR, CHEMBL2361504, HY-B1745A, Pyridoxamine dihydrochloride 10 microg/mL in Acetonitrile, BCP09064, MSK10165, Tox21_110020, AKOS015961644, Tox21_110020_1, FP27318, NCGC00013273-01, NCGC00013273-03, AC-24503, AS-11675, SY033141, Pyridoxylamine (dihydrochloride) (Standard), CS-0013765, NS00080323, P0560, P2688, Pyridoxamine dihydrochloride, >=99.0% (TLC), Pyridoxamine dihydrochloride, Cell Culture Reagent, Q27225159, Pyridoxamine dihydrochloride, analytical standard, >=98%, Pyridoxamine dihydrochloride, BioReagent, suitable for cell culture, 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL 2HCL, 4-(Aminomethyl)-3-hydroxy-5-(hydroxymethyl)-2-methylpyridine Dihydrochloride, 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride;2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxmethylpyridine dihydr ochloride

Pyridoxamine dihydrochloride is extensively used as a precursor in the synthesis of vitamin B₆-related compounds and as a reference standard in HPLC analysis. It plays a pivotal role in studying advanced glycation end-products (AGEs) due to its inhibitory effects on oxidative stress. Researchers also employ it in enzymology to investigate transamination and decarboxylation reactions. Its compatibility with cell culture systems makes it valuable for nutrient supplementation studies.

Safety and Hazards

GHS Hazard Statements

• H315 (97.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.7%)
• Eye Irrit. 2 (97.7%)
• STOT SE 3 (95.3%)

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