Description

Pyridine-3-sulfonyl chloride (CAS No. 16133-25-8) is a high-purity sulfonyl chloride derivative of pyridine, widely utilized in organic synthesis and pharmaceutical research. With the molecular formula C₅H₄ClNO₂S, this compound serves as a versatile reagent for introducing sulfonyl groups into target molecules. Its IUPAC name, pyridine-3-sulfonyl chloride, reflects its precise structural configuration, featuring a reactive sulfonyl chloride moiety at the 3-position of the pyridine ring. This product is rigorously tested for quality, ensuring optimal performance in coupling reactions, sulfonamide formation, and other synthetic transformations. Suitable for laboratory and industrial applications, it is available in various packaging options to meet your research needs.

Properties

• CAS Number: 16133-25-8
• Complexity: 196
• IUPAC Name: pyridine-3-sulfonyl chloride
• InChI: InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H
• InChI Key: CDRNYKLYADJTMN-UHFFFAOYSA-N
• Exact Mass: 176.9651272
• Molecular Formula: C5H4ClNO2S
• Molecular Weight: 177.61
• SMILES: C1=CC(=CN=C1)S(=O)(=O)Cl
• Topological: 55.4
• Monoisotopic Mass: 176.9651272
• Synonyms: Pyridine-3-sulfonyl chloride, 16133-25-8, 3-Pyridinesulfonyl chloride, DTXSID70936483, DTXCID80970398, 688-270-1, pyridine-3-sulfonylchloride, 813222-82-1, chloro-3-pyridylsulfone, 3-Pyridylsulfonyl chloride, m-Pyridinesulfonyl Chloride, MFCD03452747, GenBank CX447129 (9CI), 3-pyridinesulfonylchloride, 3-pyridinesulphonylchloride, 3-pyridinylsulfonyl chloride, pyrid-3-ylsulfonyl chloride, pyridin-3-sulfonyl chloride, pyridine-3-sulphonylchloride, 3-pyridine sulfonyl chloride, SCHEMBL17072, pyridin-3-ylsulfonyl chloride, QB86L75A7T, pyridine-3-sulfonyl hydrochloride, BCP12293, PYRIDINE-3-SULPHONYL CHLORIDE, SBB010621, STK802246, AKOS000265497, AB15457, CS-W008940, FP64081, SB10035, AC-29288, BS-13229, DB-183649, P1935, EN300-30525, Z300074856, Pyridine-3-sulfonyl chloride, for HPLC derivatization, >=98.0% (GC)

Application

Pyridine-3-sulfonyl chloride is commonly employed as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals. It is particularly useful in medicinal chemistry for modifying bioactive molecules to enhance their pharmacokinetic properties. Researchers also utilize this reagent in peptide coupling reactions and as a precursor for sulfonate esters. Its reactivity makes it valuable in cross-coupling and functionalization reactions in organic synthesis.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (13.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• STOT SE 3 (13.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.