Description

Description

1,1,1,2,2-Pentafluoro-3-iodopropane (CAS No. 354-69-8) is a highly specialized fluorinated organic compound with the molecular formula C₃H₂F₅I. This iodine-substituted pentafluoropropane is a valuable intermediate in synthetic organic chemistry, particularly in the preparation of fluorinated compounds used in pharmaceuticals, agrochemicals, and advanced materials. Its unique structure, featuring a pentafluoroalkyl group and an iodine substituent, makes it an excellent candidate for nucleophilic substitution reactions, radical reactions, and as a building block for further functionalization. The compound is supplied as a high-purity liquid (typically >98% purity by GC) and should be stored under inert conditions to maintain stability. Due to its reactive iodine moiety, it is widely utilized in cross-coupling reactions and as a precursor for introducing fluorinated segments into complex molecules. Researchers appreciate its utility in creating compounds with enhanced lipophilicity and metabolic stability.

Application

1,1,1,2,2-Pentafluoro-3-iodopropane is primarily used as a key synthon in the synthesis of fluorinated pharmaceuticals and agrochemicals, where its pentafluoroalkyl group enhances bioavailability and chemical stability. It serves as a versatile intermediate in palladium-catalyzed cross-coupling reactions, such as the Heck and Suzuki reactions, enabling the introduction of fluorinated motifs into aromatic systems. Additionally, this compound is employed in materials science for the development of fluorinated polymers and surfactants with unique hydrophobic and oleophobic properties. Its reactivity with nucleophiles also makes it valuable for constructing complex fluorinated scaffolds in medicinal chemistry.

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