Description

2,2,3,3,3-Pentafluoropropanamide (CAS No. 354-76-7) is a high-purity fluorinated organic compound with the molecular formula C₃H₂F₅NO. This specialty chemical features a pentafluorinated propyl backbone coupled with an amide functional group, making it a valuable intermediate for advanced synthetic applications. Its unique structure imparts exceptional chemical stability, thermal resistance, and reactivity, suitable for use in pharmaceuticals, agrochemicals, and material science research. Available in >98% purity (GC), this compound is rigorously tested for consistency and performance. Ideal for researchers exploring fluorinated building blocks, nucleophilic substitutions, or amide-based derivatization. Packaged under inert gas to ensure stability and supplied with comprehensive analytical data (MSDS, NMR, HPLC).

Properties

• CAS Number: 354-76-7
• Complexity: 149
• IUPAC Name: 2,2,3,3,3-pentafluoropropanamide
• InChI: InChI=1S/C3H2F5NO/c4-2(5,1(9)10)3(6,7)8/h(H2,9,10)
• InChI Key: KQTOYEUYHXUEDB-UHFFFAOYSA-N
• Exact Mass: 163.00565450
• Molecular Formula: C3H2F5NO
• Molecular Weight: 163.05
• SMILES: C(=O)(C(C(F)(F)F)(F)F)N
• Topological: 43.1
• Monoisotopic Mass: 163.00565450
• Synonyms: Pentafluoropropionamide, 2,2,3,3,3-Pentafluoropropanamide, Propanamide, 2,2,3,3,3-pentafluoro-, 2,2,3,3,3-Pentafluoropropionamide, EINECS 206-569-3, 206-569-3, 354-76-7, pentafluoropropanamide, Perfluoropropanamide, C3H2F5NO, MFCD00039771, SCHEMBL808847, SCHEMBL808848, Pentafluoro propionic acid amide, DTXSID0059871, HEADDNLPINIYNL-UHFFFAOYSA-N, SBB057872, AKOS003269747, 2,2,3,3,3-Pentafluoropropanamide #, AS-60985, DB-048823, NS00018972, P1316, ST51007173, EN300-39929, Z406353702

Application

2,2,3,3,3-Pentafluoropropanamide serves as a key fluorinated synthon in pharmaceutical research, particularly for designing metabolically stable analogs. It is utilized in agrochemical development to enhance pesticide bioavailability and environmental persistence. The compound’s electron-withdrawing pentafluoro moiety also makes it valuable for studying reaction mechanisms in organofluorine chemistry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.