Description

(R)-Prolinol (C₅H₁₁NO, CAS No. 68832-13-3) is a high-purity chiral compound widely used in asymmetric synthesis, pharmaceutical research, and fine chemical production. This enantiomerically pure secondary alcohol features a pyrrolidine ring with a hydroxymethyl substituent, making it a versatile building block for catalysts, ligands, and intermediates. With a molecular weight of 101.15 g/mol, it is supplied as a colorless to pale yellow liquid (or low-melting solid) with ≥98% purity (GC). Its stereochemical integrity and functional group reactivity enable applications in medicinal chemistry, including the synthesis of bioactive molecules and chiral auxiliaries. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 68832-13-3
• Complexity: 56
• IUPAC Name: [(2R)-pyrrolidin-2-yl]methanol
• InChI: InChI=1S/C5H11NO/c7-4-5-2-1-3-6-5/h5-7H,1-4H2/t5-/m1/s1
• InChI Key: HVVNJUAVDAZWCB-RXMQYKEDSA-N
• Exact Mass: 101.084063974
• Molecular Formula: C5H11NO
• Molecular Weight: 101.15
• SMILES: C1C[C@@H](NC1)CO
• Topological: 32.3
• Monoisotopic Mass: 101.084063974
• Synonyms: D-Prolinol, 68832-13-3, (R)-Pyrrolidin-2-ylmethanol, (2R)-pyrrolidin-2-ylmethanol, [(2R)-pyrrolidin-2-yl]methanol, (2r)-2-pyrrolidinemethanol, (R)-PROLINOL, 2-PYRROLIDINEMETHANOL, (2R)-, (R)-2-PYRROLIDINEMETHANOL, (R)-(-)-2-(Hydroxymethyl)pyrrolidine, Prolinol, (R)-, (R)-(-)-PROLINOL, (R)-1-Pyrrolidin-2-ylmethanol, (-)-2-pyrrolidinemethanol, (r)-pyrrolidin-2-methanol, 2-Pyrrolidinemethanol, (R)-, (R)-2-(HYDROXYMETHYL)PYRROLIDINE, (2R)-2-Hydroxymethylpyrrolidine, (r)-(-)-pyrrolidine-2-methanol, H52Z235V6Y, (R)-1-(Pyrrolidin-2-yl)methanol, L-(Pyrrolidin-1-yl)methanol, CHEBI:84258, DTXSID301020303, ((2R)-pyrrolidin-2-yl)methanol, DTXCID401326801, 245-605-2, 629-147-4, (R)-(-)-2-Pyrrolidinemethanol, (R)-1-Pyrrolidin-2-yl-methanol, MFCD00064321, (R)-2-HYDROXYMETHYLPYRROLIDINE, D-(-)-Prolinol, ((2R)pyrrolidin-2-yl)methan-1-ol, 2-Pyrrolidinylmethanol #, (R)-Pyrrolidin-2-yl-methanol, (R)-2-hydroxymethyl-pyrrolidine, (D)-prolinol, (R)-2-Pyrrolidine methanol, SCHEMBL19071, (2R)-2-pyrrolidinylmethanol, (R)-pyrolidin-2-yl-methanol, (R)-pyrrolidine-2-ylmethanol, SCHEMBL384800, UNII-H52Z235V6Y, (R)-pyrrolidin-2-yl methanol, (R)-pyrrolidine-2-yl-methanol, SCHEMBL2388221, SCHEMBL5413819, (R)-2-(hydroxymethyl)pyrrolidin, (2R)-2-hydroxymethyl-pyrrolidine, (R)-(-)-2-Pyrrolidinylmethanol, (r)-(-)-2-pyrrolidine methanol, CS-D1509, STR08866, (R)-(-)-pyrrolidin-2-yl-methanol, SBB027252, AKOS000301897, AKOS005259748, (R)-(-)-2-(Hydroxymethyl)pyrrolidin, PS-9312, (R)-(-)-2-(hydroxymethyl)-pyrrolidine, (R)-(-)-2-Pyrrolidinemethanol, 99%, 32-13-3, AC-23551, BP-14079, DB-230304, P1274, ST50336377, EN300-54891, (2R)-(-)-2-(HYDROXYMETHYL)PYRROLIDINE, Q7249621, D-Prolinol, purum, >=98.0% (sum of enantiomers, GC), 8GZ

(R)-Prolinol serves as a key precursor for chiral ligands in transition-metal catalysis and organocatalysis. It is employed in asymmetric C-C bond formations and enantioselective reductions. Researchers utilize it to synthesize proline derivatives for peptide mimetics and pharmaceutical intermediates. Its hydroxyl group allows for further functionalization in heterocycle synthesis.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (89.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (94.7%)
• Eye Irrit. 2 (94.7%)
• STOT SE 3 (91.2%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.