Description

Procarbazine Hydrochloride (CAS No. 366-70-1) is a high-purity pharmaceutical compound with the molecular formula C12H20ClN3O. This hydrazine derivative is widely recognized for its role as an alkylating antineoplastic agent, primarily used in chemotherapy regimens. Procarbazine Hydrochloride is supplied as a white to pale yellow crystalline powder, ensuring optimal solubility and stability for research and clinical applications. Our product meets stringent quality standards, including HPLC purity ≥98%, making it ideal for in vitro and in vivo studies. Each batch undergoes rigorous analytical testing (NMR, MS, elemental analysis) to guarantee consistency. Available in research quantities (mg to kg scale) with customizable packaging under inert atmosphere for enhanced shelf life. SDS and CoA provided upon request.

Properties

• CAS Number: 366-70-1
• Complexity: 210
• IUPAC Name: N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;hydrochloride
• InChI: InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• InChI Key: DERJYEZSLHIUKF-UHFFFAOYSA-N
• Exact Mass: 257.1294900
• Molecular Formula: C12H20ClN3O
• Molecular Weight: 257.76
• SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
• Topological: 53.2
• Monoisotopic Mass: 257.1294900
• Physical Description: Procarbazine hydrochloride is a white to pale yellow crystalline powder with a slight odor. Acid to litmus.
• Melting Point: 433 °F
• Solubility: greater than or equal to 100 mg/mL at 70.7 °F
• Synonyms: Procarbazine hydrochloride, 366-70-1, PROCARBAZINE HCl, Nathulane, Natunalar, MIH hydrochloride, PCB hydrochloride, Ibenzmethyzine hydrochloride, Natulan hydrochloride, NSC-77213, Procarbazine chloridrate, Ibenzmethyzin hydrochloride, NCI-C01810, CCRIS 531, CHEBI:71428, UNII-XH0NPH5ZX8, Ro 4-6467/1, XH0NPH5ZX8, EINECS 206-678-6, NSC 77213, p-(N’-Methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride, DTXSID3021190, AI3-50844, RO-4-6467 HYDROCHLORIDE, NSC77213, NCI-C 01810, NCI-C-01810, 1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride, 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride, 1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride, N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride, MBH, 2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride, N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride, Procarbazine Monohydrochloride, Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, monohydrochloride, Ro 4 6467/1, DTXCID001190, N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide monohydrochloride, p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, hydrochloride, Procarbazine hydrochloride [USAN:USP:JAN], Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride, p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride, Natulanar, IBZ, N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride, PROCARBAZINE HYDROCHLORIDE (IARC), PROCARBAZINE HYDROCHLORIDE [IARC], PROCARBAZINE HYDROCHLORIDE (MART.), PROCARBAZINE HYDROCHLORIDE [MART.], PROCARBAZINE HYDROCHLORIDE (USP-RS), PROCARBAZINE HYDROCHLORIDE [USP-RS], Procarbazine hydrochloride (USAN:USP:JAN), PROCARBAZINE HYDROCHLORIDE (USP MONOGRAPH), PROCARBAZINE HYDROCHLORIDE [USP MONOGRAPH], Hydrochloride, Procarbazine, Monohydrochloride, Procarbazine, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide monohydrochloride, (P-N’-(1-METHYLHYDRAZINOMETHYL)-N-ISOPROPYL) BENZAMIDE, N-4-isopropylcarbamoylbenzyl-N’-methylhydrazine Hydrochloride, 1-METHYL-2-(P-(ISOPROPYLCARBAMOYL)BENZYL)HYDRAZINE HYDROCHLORIDE, 1-METHYL-2-P-(ISOPROPYLCARBAMOYL)BENZYLHYDRAZINE HYDROCHLORIDE, benzamide, N-(1-methylethyl)-4-((2-methylhydrazino) methyl)-, monohydrochloride, 206-678-6, pcz, Matulane, Natulan, Procarbazine.HCl, Procarbazine (Hydrochloride), N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride, MFCD00072082, 366-70-1 (HCl), Procarbazine hydrochloride (Matulane), Ro-46467/1, NCGC00016438-01, CAS-366-70-1, Ro-4-6467/1, SR-01000763375, Matulane (TN), N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide hydrochloride, Procarbazini hydrochloridum, Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine [French], SCHEMBL4012, MLS001401414, p-Toluamide, monohydrochloride, NSC-77213 HCl, CHEMBL1200410, GLXC-21156, HMS1571O06, BCP02880, Procarbazine hydrochloride (Natulan), Tox21_110439, Tox21_302318, 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide hydrochloride, 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride, BDBM50247906, HY-13733R, s1995, WLN: 1Y1&MVR D1MM1 &GH, Procarbazine HCl – Bio-X trade mark, 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide hydrochloride, AKOS015895395, Tox21_110439_1, CCG-100985, FP27166, NC00235, Procarbazine hydrochloride (JP18/USP), PROCARBAZINE HYDROCHLORIDE [MI], Procarbazine (Hydrochloride) (Standard), PROCARBAZINE HYDROCHLORIDE [JAN], NCGC00016438-04, NCGC00255389-01, PROCARBAZINE HYDROCHLORIDE [USAN], AC-12163, AS-13285, BP164298, HY-13733, PROCARBAZINE HYDROCHLORIDE [VANDF], Ro 4-646711, SMR000469151, BCP0726000264, PROCARBAZINE HYDROCHLORIDE [WHO-DD], PROCARBAZINE HYDROCHLORIDE [WHO-IP], DB-048987, Procarbazine hydrochloride, >=98% (HPLC), NS00079410, P2550, C07376, D00478, EN300-122365, PROCARBAZINE HYDROCHLORIDE [ORANGE BOOK], PROCARBAZINI HYDROCHLORIDUM [WHO-IP LATIN], SR-01000763375-4, Q26840941, Z1541759748, methyl-[[4-(propan-2-ylcarbamoyl)phenyl]methylamino]azanium;chloride, N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamidehydrochloride, 4-[(2-methyl-hydrazino)-methyl]-benzoic acid isopropylamide hydrochloride, N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride, N-ISOPROPYL-.ALPHA.-(2-METHYLHYDRAZINO)-P-TOLUAMIDE MONOHYDROCHLORIDE, Procarbazine hydrochloride, United States Pharmacopeia (USP) Reference Standard, N-(1-Methylethyl)-4-(2-methylhydrazino)methylbenzamide hydrochloride;N-Isopropyl-(2-methylhydrazino)-p-toluamide-hydrochloride;M, N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride;N-Isopropyl-(2-methylhydrazino)-p-toluamide-hydrochloride;Mut ulane

Procarbazine Hydrochloride is a key component in MOPP (mechlorethamine, vincristine, procarbazine, prednisone) chemotherapy for Hodgkin’s lymphoma. It acts as a DNA methylating agent through metabolic activation, inducing DNA strand breaks and inhibiting nucleic acid synthesis. This compound is also used in research investigating drug resistance mechanisms and combination therapies for brain tumors. Laboratory studies employ it at concentrations of 1-100 μM depending on experimental models.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H341 (97.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H350 (100%): May cause cancer [Danger Carcinogenicity]
• H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Precautionary Statements

• P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Muta. 2 (97.6%)
• Carc. 1B (100%)
• Repr. 1A (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.