Description

Description

Potassium (1-((tert-butoxy)carbonyl)pyrrolidin-2-yl)trifluoroboranuide (CAS: 1684443-00-2) is a high-purity organoboron compound with the molecular formula C₉H₁₆BF₃KNO₂. This advanced synthetic intermediate features a tert-butoxycarbonyl (Boc)-protected pyrrolidine ring coupled with a potassium trifluoroborate moiety, making it an exceptionally versatile building block for pharmaceutical research and peptide chemistry. The compound’s IUPAC name is potassium;trifluoro-[1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]boranuide. With a molecular weight of 273.14 g/mol, it is supplied as a stable, crystalline solid under inert conditions to ensure optimal shelf life. Ideal for Suzuki-Miyaura cross-coupling reactions, this reagent offers excellent solubility in polar organic solvents while maintaining compatibility with air- and moisture-sensitive protocols. Each batch undergoes rigorous QC testing (HPLC, NMR) to guarantee ??95% purity for demanding synthetic applications.

Application

This potassium trifluoroborate derivative serves as a critical precursor in medicinal chemistry for the synthesis of N-Boc-protected pyrrolidine scaffolds, which are widely used in protease inhibitor development. The trifluoroborate group enhances stability while retaining reactivity in palladium-catalyzed cross-couplings, particularly for constructing chiral centers in drug candidates. Researchers utilize it in fragment-based drug discovery and as a handle for late-stage functionalization of bioactive molecules.

If you are interested or have any questions, please contact us at support@atomfair.com