Description

Picolinohydrazide (CAS: 1452-63-7) is a high-purity organic compound with the molecular formula C₆H₇N₃O. This heterocyclic hydrazide derivative is widely utilized in pharmaceutical research, coordination chemistry, and material science due to its versatile chelating properties and structural adaptability. As a derivative of picolinic acid, it serves as a key intermediate in the synthesis of bioactive molecules, metal-organic frameworks (MOFs), and ligands for catalysis. Available in crystalline powder form, our Picolinohydrazide meets rigorous analytical standards (≥98% purity by HPLC) and is supplied with comprehensive characterization data including NMR, MS, and FTIR spectra. Suitable for use under inert conditions, this product is packaged in amber glass vials with argon flushing to ensure long-term stability. Researchers rely on this compound for its consistent performance in nucleophilic reactions, Schiff base formation, and as a precursor in medicinal chemistry applications.

Properties

• CAS Number: 1452-63-7
• Complexity: 126
• IUPAC Name: pyridine-2-carbohydrazide
• InChI: InChI=1S/C6H7N3O/c7-9-6(10)5-3-1-2-4-8-5/h1-4H,7H2,(H,9,10)
• InChI Key: BAQLNPIEFOYKNB-UHFFFAOYSA-N
• Exact Mass: 137.058911855
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.14
• SMILES: C1=CC=NC(=C1)C(=O)NN
• Topological: 68
• Monoisotopic Mass: 137.058911855
• Synonyms: picolinohydrazide, 1452-63-7, 2-Isoniazid, Picolinic Acid Hydrazide, 2-Pyridinecarboxylic acid, hydrazide, KS1CG3S7U1, NSC 81875, NSC-81875, .ALPHA.-PICOLINOHYDRAZIDE, DTXSID40162934, 2-(HYDRAZINOCARBONYL)PYRIDINE, 2-PYRIDINECARBOXYLIC HYDRAZIDE, ALPHA-PICOLINOHYDRAZIDE, DTXCID3085425, 675-820-0, pyridine-2-carbohydrazide, 2-Picolinyl Hydrazide, Pyridine-2-carboxylic acid hydrazide, 2-Pyridinecarbohydrazide, 2-Pyridinecarboxylic acid hydrazide, Picolinic acid, hydrazide, MFCD00059782, NSC81875, Pyridinecarboxylic acid, hydrazide, picolinichydrazone, Pyridine Hydrazide, Pyridine 2-Hydrazide, 2-Pyridinecarbohydrazide #, UNII-KS1CG3S7U1, .alpha.-Picolinyl hydrazide, NCIOpen2_000798, SCHEMBL109657, pyridine, 2-hydrazinocarbonyl-, CHEMBL331508, SCHEMBL2441765, SCHEMBL4754861, SCHEMBL4754862, SCHEMBL28131851, pyridine carboxylic acid hydrazide, pyridine-carboxylic acid hydrazide, 2-Pyridinecarboxylicacid,hydrazide, ALBB-001060, BCP32025, Pyridin-2-carboxylic acid hydrazide, 2-Pyridinecarbohydrazide, AldrichCPR, BBL003530, SBB027572, STK095237, AKOS000264965, CS-W011057, HY-W010341, PD055631, SY021575, DB-063597, P0426, ST45028736, EN300-03839, Z56922131, F3339-0440, Picolinohydrazide;2-Picolinyl Hydrazide;2-Isoniazid Impurity

Picolinohydrazide is extensively employed as a chelating agent in the preparation of transition metal complexes for catalytic applications. It serves as a versatile building block in medicinal chemistry for the synthesis of antitubercular and antimicrobial agents. The compound finds use in material science for constructing metal-organic frameworks with tailored porosity. Researchers utilize its hydrazide functionality for developing fluorescence probes and sensors. In pharmaceutical quality control, it serves as a reference standard for impurity profiling of related drug substances.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (25%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (25%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.