Description

Description

Pentafluorophenol (CAS No. 771-61-9) is a highly fluorinated aromatic compound with the molecular formula C₆HF₅O. This specialty chemical, also known by its IUPAC name 2,3,4,5,6-pentafluorophenol, is characterized by its five fluorine atoms attached to a phenol ring, enhancing its reactivity and utility in organic synthesis. Pentafluorophenol is a white to off-white crystalline solid with a melting point of approximately 36-38??C and a boiling point of 143-145??C. It is soluble in organic solvents such as methanol, ethanol, and dichloromethane, but exhibits limited solubility in water. This compound is widely used as a derivatization agent, catalyst, and intermediate in pharmaceuticals, agrochemicals, and materials science. Its electron-withdrawing fluorine atoms make it an excellent leaving group in nucleophilic substitution reactions. Pentafluorophenol is supplied with high purity (>98%) and is packaged under inert conditions to ensure stability and longevity. Suitable for research and industrial applications, it is handled with care due to its potential irritant properties.

Application

Pentafluorophenol is extensively employed as a versatile reagent in organic synthesis, particularly as a leaving group in peptide coupling reactions and esterifications. It serves as a key intermediate in the preparation of pharmaceuticals, agrochemicals, and advanced materials due to its high reactivity and stability. In analytical chemistry, it is used as a derivatization agent for gas chromatography and mass spectrometry to enhance detection sensitivity. Additionally, Pentafluorophenol finds applications in polymer chemistry as a monomer or cross-linking agent for fluorinated polymers. Its unique electronic properties also make it valuable in catalysis and ligand design for transition metal complexes.

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