Description

P-Toluic Acid (4-Methylbenzoic Acid) is a high-purity aromatic carboxylic acid with the molecular formula C₈H₈O₂ (CAS: 99-94-5). This white crystalline solid is a key intermediate in organic synthesis, offering excellent solubility in alcohols and ethers while being sparingly soluble in water. Our pharmaceutical-grade P-Toluic Acid is meticulously purified to ≥99% purity (HPLC) with controlled moisture content (<0.5%), making it ideal for sensitive applications. The product undergoes rigorous QC testing including FTIR, NMR, and GC-MS validation to ensure batch-to-batch consistency. Available in research quantities (100g, 500g) or bulk orders (25kg drums), each unit is packaged in amber glass bottles with PTFE-lined caps or HDPE containers with desiccant packs for optimal stability. Technical datasheets include detailed spectral data, safety information (SDS), and regulatory compliance documentation (REACH, USP).

Properties

• CAS Number: 99-94-5
• Complexity: 123
• IUPAC Name: 4-methylbenzoic acid
• InChI: InChI=1S/C8H8O2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3,(H,9,10)
• InChI Key: LPNBBFKOUUSUDB-UHFFFAOYSA-N
• LogP: 2.27
• Exact Mass: 136.052429494
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• SMILES: CC1=CC=C(C=C1)C(=O)O
• Topological: 37.3
• Monoisotopic Mass: 136.052429494
• Physical Description: P-toluic acid is a white powder. Sublimes.
• Boiling Point: 525 to 527 °F at 760 mmHg
• Melting Point: 356 to 360 °F
• Solubility: less than 1 mg/mL at 66 °F
• Vapor Pressure: 0.0061 [mmHg]
• Synonyms: 4-Methylbenzoic acid, P-TOLUIC ACID, 99-94-5, 4-Toluic acid, p-Methylbenzoic acid, Benzoic acid, 4-methyl-, Crithminic acid, p-Toluylic acid, p-Carboxytoluene, para-Toluic acid, 4-Methyl-Benzoic Acid, NSC 2215, A26GBX5SSV, EINECS 202-803-3, BRN 0507600, DTXSID6021618, p-Tolylcarboxylic acid, CHEBI:36635, AI3-15627, NSC-2215, TOLUIC ACID, P-, P-TOLUIC ACID [MI], DTXCID801618, p-methylbenzoate, p-toluenecarboxylate, pCarboxytoluene, pToluylic acid, 4toluic acid, pMethylbenzoic acid, 4methylbenzoic acid, pTolylcarboxylic acid, Benzoic acid, 4methyl, 202-803-3, inchi=1/c8h8o2/c1-6-2-4-7(5-3-6)8(9)10/h2-5h,1h3,(h,9,10, Toluate, Toluenecarboxylic acid, MFCD00002565, 4-Methyl benzoic acid, p-toluic-2,3,5,6-d4 acid, Supported benzoic acid (100-200/2.5-3.0), 4-Methylbenzoic acid(Flakes or Chunks or Granular), p-toluicacid, 4MA, 4-MethylbenzoicAcid, UNII-A26GBX5SSV, Crithmic acid, rho-toluic acid, para toluic acid, 4-methylbenzic acid, p-methyl benzoic acid, p-Toluic acid, 98%, Benzoic acid,4-methyl-, bmse000414, WLN: QVR D1, NCIOpen2_001271, SAMPL4, O2, SCHEMBL93638, SCHEMBL94869, 4-methylbenzenecarboxylic acid, CHEMBL21708, SCHEMBL409672, SCHEMBL1869090, SCHEMBL4305389, SCHEMBL16267153, NSC2215, 2420-97-5 (cadmium salt), BDBM197303, p-Toluic acid, analytical standard, CS-D0602, Tox21_201091, SBB040516, STK498227, AKOS000119644, AC-3061, BS-3777, FT38107, CAS-99-94-5, NCGC00091128-01, NCGC00091128-02, NCGC00258643-01, HY-76547, SY003713, NS00005898, ST50213865, T0293, EN300-18325, C01454, D70680, p-Toluic acid, Vetec(TM) reagent grade, 98%, AB-131/40170882, Q1607905, Z57902424, F1679-0157, 4-Methylbenzoic acid; p-Toluylic acid; Crithminic acid; Toluenecarboxylic acid

Application

P-Toluic Acid serves as a crucial building block in pharmaceutical synthesis, particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and liquid crystal precursors. In material science, it functions as a monomer for specialty polyesters and as a corrosion inhibitor in industrial formulations. Researchers utilize its carboxyl group for peptide coupling reactions and as a standard in HPLC method development for aromatic acid separations.

Safety and Hazards

GHS Hazard Statements

• H315 (10.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (86.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (11.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (10.6%)
• Skin Sens. 1 (86.7%)
• Eye Irrit. 2A (11.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.